Literature DB >> 19203009

The death of molecular biology?

Michel Morange1.   

Abstract

In recent decades the expression "molecular biology" has progressively disappeared from journals, and no longer designates new chairs or departments. This begs the question: does it mean that molecular biology is dead, and has been displaced by new emerging disciplines such as systems biology and synthetic biology? Maybe its reductionist approach to living phenomena has been substituted by one that is more holistic. The situation, undoubtedly, is far less simple. To appreciate better what has happened it is necessary to acknowledge the following: the intial project of molecular biologists was not a reductionist one, but an attempt to naturalize the phenomena of life by using the epistemological principles of physics as a model; and, it is necessary to distinguish the early stages of molecular biology, and the later aggregating process which gave it its present characteristics. Only one of these characteristics, the importance of the informational vision, has been seriously challenged in recent years. But it is obvious that the ambition of most early molecular biologists to discover simple rules and principles explaining all of biological facts has vanished. The pendulum has now moved toward the study of the diversity generated by a long evolutionary history.

Mesh:

Year:  2008        PMID: 19203009

Source DB:  PubMed          Journal:  Hist Philos Life Sci        ISSN: 0391-9714            Impact factor:   1.205


  4 in total

1.  The Bermuda Triangle: The Pragmatics, Policies, and Principles for Data Sharing in the History of the Human Genome Project.

Authors:  Kathryn Maxson Jones; Rachel A Ankeny; Robert Cook-Deegan
Journal:  J Hist Biol       Date:  2018-12       Impact factor: 1.326

2.  A new revolution? The place of systems biology and synthetic biology in the history of biology.

Authors:  Michel Morange
Journal:  EMBO Rep       Date:  2009-08       Impact factor: 8.807

3.  The "Genetic Program": Behind the Genesis of an Influential Metaphor.

Authors:  Alexandre E Peluffo
Journal:  Genetics       Date:  2015-07       Impact factor: 4.562

Review 4.  So what do we really mean when we say that systems biology is holistic?

Authors:  Derek Gatherer
Journal:  BMC Syst Biol       Date:  2010-03-12
  4 in total

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