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Literature DB >> 19201806

Rrp2, a sigma54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner.

Jon S Blevins¹, Haijun Xu, Ming He, Michael V Norgard, Larry Reitzer, X Frank Yang.

Abstract

Rrp2 is the sole sigma(54)-dependent transcriptional activator present in the Borrelia burgdorferi genome. We showed that recombinant Rrp2 binds to DNA in a sequence-nonspecific manner. During infection, Rrp2 activates sigma(54)-dependent rpoS expression without an apparent upstream enhancer element commonly associated with other sigma(54)-dependent transcriptional activators.

Entities: Disease Species

Mesh：

Substances：

Year: 2009 PMID： 19201806 PMCID： PMC2668385 DOI： 10.1128/JB.01721-08

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

26 in total

Review 1. Look, no hands! Unconventional transcriptional activators in bacteria.

Authors: L Lauren Beck; Todd G Smith; Timothy R Hoover
Journal: Trends Microbiol Date: 2007-11-09 Impact factor: 17.079

2. Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators.

Authors: D Yan; H S Cho; C A Hastings; M M Igo; S Y Lee; J G Pelton; V Stewart; D E Wemmer; S Kustu
Journal: Proc Natl Acad Sci U S A Date: 1999-12-21 Impact factor: 11.205

3. Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway.

Authors: A Hübner; X Yang; D M Nolen; T G Popova; F C Cabello; M V Norgard
Journal: Proc Natl Acad Sci U S A Date: 2001-10-23 Impact factor: 11.205

4. Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi.

Authors: Bethany K Boardman; Ming He; Zhiming Ouyang; Haijun Xu; Xiujuan Pang; X Frank Yang
Journal: Infect Immun Date: 2008-06-23 Impact factor: 3.441

5. Analysis of the Campylobacter jejuni FlgR response regulator suggests integration of diverse mechanisms to activate an NtrC-like protein.

Authors: Stephanie N Joslin; David R Hendrixson
Journal: J Bacteriol Date: 2008-01-25 Impact factor: 3.490

6. Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi.

Authors: Zhiming Ouyang; Jon S Blevins; Michael V Norgard
Journal: Microbiology (Reading) Date: 2008-09 Impact factor: 2.777

7. Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferi.

Authors: Meghan C Lybecker; D Scott Samuels
Journal: Mol Microbiol Date: 2007-05 Impact factor: 3.501

Review 8. Domain architectures of sigma54-dependent transcriptional activators.

Authors: David J Studholme; Ray Dixon
Journal: J Bacteriol Date: 2003-03 Impact factor: 3.490

9. Insights into the complex regulation of rpoS in Borrelia burgdorferi.

Authors: Mary N Burtnick; Jennifer S Downey; Paul J Brett; Julie A Boylan; Jonathan G Frye; Timothy R Hoover; Frank C Gherardini
Journal: Mol Microbiol Date: 2007-06-21 Impact factor: 3.501

10. Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection.

Authors: Jon S Blevins; Kayla E Hagman; Michael V Norgard
Journal: BMC Microbiol Date: 2008-05-28 Impact factor: 3.605

38 in total

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Authors: S L Rajasekhar Karna; Eva Sanjuan; Maria D Esteve-Gassent; Christine L Miller; Mahulena Maruskova; J Seshu
Journal: Infect Immun Date: 2010-11-15 Impact factor: 3.441

2. The Fur homologue BosR requires Arg39 to activate rpoS transcription in Borrelia burgdorferi and thereby direct spirochaete infection in mice.

Authors: Laura I Katona
Journal: Microbiology Date: 2015-08-27 Impact factor: 2.777

3. Evidence that BosR (BB0647) Is a Positive Autoregulator in Borrelia burgdorferi.

Authors: Zhiming Ouyang; Jianli Zhou; Michael V Norgard
Journal: Infect Immun Date: 2016-08-19 Impact factor: 3.441

4. Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferi.

Authors: Meghan C Lybecker; Cassandra A Abel; Andrew L Feig; D Scott Samuels
Journal: Mol Microbiol Date: 2010-09-27 Impact factor: 3.501

5. The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.

Authors: Christian H Eggers; Melissa J Caimano; Robert A Malizia; Toru Kariu; Brian Cusack; Daniel C Desrosiers; Karsten R O Hazlett; Al Claiborne; Utpal Pal; Justin D Radolf
Journal: Mol Microbiol Date: 2011-10-12 Impact factor: 3.501

6. The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks.

Authors: Melissa J Caimano; Melisha R Kenedy; Toru Kairu; Daniel C Desrosiers; Michael Harman; Star Dunham-Ems; Darrin R Akins; Utpal Pal; Justin D Radolf
Journal: Infect Immun Date: 2011-05-23 Impact factor: 3.441