| Literature DB >> 19201606 |
Hao Zhang1, Denis E Ryono, Pratik Devasthale, Wei Wang, Kevin O'Malley, Dennis Farrelly, Liqun Gu, Thomas Harrity, Michael Cap, Cuixia Chu, Kenneth Locke, Litao Zhang, Jonathan Lippy, Lori Kunselman, Nathan Morgan, Neil Flynn, Lisa Moore, Vinayak Hosagrahara, Lisa Zhang, Pathanjali Kadiyala, Carrie Xu, Arthur M Doweyko, Aneka Bell, Chiehying Chang, Jodi Muckelbauer, Robert Zahler, Narayanan Hariharan, Peter T W Cheng.
Abstract
The design, synthesis and structure-activity relationships of a novel series of N-phenyl-substituted pyrrole, 1,2-pyrazole and 1,2,3-triazole acid analogs as PPAR ligands are outlined. The triazole acid analogs 3f and 4f were identified as potent dual PPARalpha/gamma agonists both in binding and functional assays in vitro. The 3-oxybenzyl triazole acetic acid analog 3f showed excellent glucose and triglyceride lowering in diabetic db/db mice.Entities:
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Year: 2009 PMID： 19201606 DOI： 10.1016/j.bmcl.2009.01.030
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823