| Literature DB >> 19201382 |
Shogo Kawaguchi1, Yoh Ishiguro, Tadaatsu Imaizumi, Fumiaki Mori, Tomoh Matsumiya, Hidemi Yoshida, Ken Ota, Hirotake Sakuraba, Kazufumi Yamagata, Yuki Sato, Kunikazu Tanji, Toshihiro Haga, Koichi Wakabayashi, Shinsaku Fukuda, Kei Satoh.
Abstract
Retinoic acid-inducible gene-I (RIG-I) is a member of the DExH/D family proteins, and plays an important role in antiviral response via interferon-stimulated genes (ISGs) and type 1 IFN. In this study, the roles of RIG-I in the epithelial cells in the cross-talk between type 2 IFN and inducible chemokines production are high-lighted. The results showed that RIG-I was constitutively expressed in normal surface epithelia lining the colonic mucosa. RIG-I was constitutively expressed in the epithelial cell lines HT-29, and IFN-gamma and TNF-alpha enhanced the RIG-I expression in a dose-dependent manner. IFN-gamma was shown to stimulate CXCL9-11 production, and RNA interference against RIG-I resulted in significant decrease of IFN-gamma-induced CXCL9-11 productions. These results suggest that RIG-I play an important role in the cross-talk between inflammatory cytokines and immune cell trafficking. In conclusion, RIG-I might regulate the gut barrier function in homeostatic and inflammatory conditions.Entities:
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Year: 2009 PMID： 19201382 DOI： 10.1016/j.imlet.2009.01.008
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685