BACKGROUND: This review aims to make laboratory professionals and clinicians more familiar with the basic concepts that deal with the clinical performance characteristics of a laboratory test. CONTENT: Basic measures of the clinical performance characteristics of a laboratory test, such as sensitivity, specificity, likelihoods, likelihood ratio, post-test probability, odds, Bayes theorem, and receiver-operator characteristic curve are explained. The concepts are illustrated with examples (anti-CCP antibodies) that are worked out in a spreadsheet. SUMMARY: This review seeks to provide laboratory professionals and clinicians with a better understanding of the clinical performance characteristics of a laboratory test and of evidence-based laboratory medicine. The manuscript emphasizes a strong link between clinical statistics and evidence-based laboratory medicine.
BACKGROUND: This review aims to make laboratory professionals and clinicians more familiar with the basic concepts that deal with the clinical performance characteristics of a laboratory test. CONTENT: Basic measures of the clinical performance characteristics of a laboratory test, such as sensitivity, specificity, likelihoods, likelihood ratio, post-test probability, odds, Bayes theorem, and receiver-operator characteristic curve are explained. The concepts are illustrated with examples (anti-CCP antibodies) that are worked out in a spreadsheet. SUMMARY: This review seeks to provide laboratory professionals and clinicians with a better understanding of the clinical performance characteristics of a laboratory test and of evidence-based laboratory medicine. The manuscript emphasizes a strong link between clinical statistics and evidence-based laboratory medicine.
Authors: Alena V Kundzer; Margarita V Volkova; Dimitrios P Bogdanos; Stefan Rödiger; Peter Schierack; I Generalov; Georgy A Nevinsky; Dirk Roggenbuck Journal: Immunol Res Date: 2013-07 Impact factor: 2.829
Authors: Peter Lea; Edward Keystone; Sasi Mudumba; Anthony Kahama; Shi-Fa Ding; Jennifer Hansen; Azar A Azad; Sihe Wang; Deborah Weber Journal: Clin Rev Allergy Immunol Date: 2011-08 Impact factor: 8.667
Authors: M Mahler; N Agmon-Levin; M van Liempt; Y Shoenfeld; A Waka; F Hiepe; A Swart; I Gürtler; M J Fritzler Journal: Rheumatol Int Date: 2010-12-08 Impact factor: 2.631