Literature DB >> 19200796

Exploring pluripotency with chemical genetics.

Bradley W Doble1, James R Woodgett.   

Abstract

In a recent issue of Chemistry & Biology, Bone et al. (2009) employed a chemical biology approach to probe the role of glycogen synthase kinase-3 (GSK-3), a key regulator of pluripotentiality, providing new insights and tools for modulating this process.

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Year:  2009        PMID： 19200796      PMCID： PMC4485919          DOI： 10.1016/j.stem.2009.01.005

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  9 in total

1.  Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells.

Authors:  Gautam Dravid; Zhaohui Ye; Holly Hammond; Guibin Chen; April Pyle; Peter Donovan; Xiaobing Yu; Linzhao Cheng
Journal:  Stem Cells       Date:  2005-07-07       Impact factor: 6.277

2.  Phosphoinositide 3-kinases and regulation of embryonic stem cell fate.

Authors:  M J Welham; M P Storm; E Kingham; H K Bone
Journal:  Biochem Soc Trans       Date:  2007-04       Impact factor: 5.407

3.  Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.

Authors:  Bradley W Doble; Satish Patel; Geoffrey A Wood; Lisa K Kockeritz; James R Woodgett
Journal:  Dev Cell       Date:  2007-06       Impact factor: 12.270

4.  Generation of multipotential mesendodermal progenitors from mouse embryonic stem cells via sustained Wnt pathway activation.

Authors:  Manjiri Manohar Bakre; Aina Hoi; Jamie Chen Yee Mong; Yvonne Yiling Koh; Kee Yew Wong; Lawrence W Stanton
Journal:  J Biol Chem       Date:  2007-08-21       Impact factor: 5.157

5.  Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells.

Authors:  Megan F Cole; Sarah E Johnstone; Jamie J Newman; Michael H Kagey; Richard A Young
Journal:  Genes Dev       Date:  2008-03-15       Impact factor: 11.361

6.  BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3.

Authors:  Qi Long Ying; Jennifer Nichols; Ian Chambers; Austin Smith
Journal:  Cell       Date:  2003-10-31       Impact factor: 41.582

7.  Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor.

Authors:  Noboru Sato; Laurent Meijer; Leandros Skaltsounis; Paul Greengard; Ali H Brivanlou
Journal:  Nat Med       Date:  2003-12-21       Impact factor: 53.440

8.  Synthetic small molecules that control stem cell fate.

Authors:  Sheng Ding; Tom Y H Wu; Achim Brinker; Eric C Peters; Wooyoung Hur; Nathanael S Gray; Peter G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-06       Impact factor: 11.205

9.  The ground state of embryonic stem cell self-renewal.

Authors:  Qi-Long Ying; Jason Wray; Jennifer Nichols; Laura Batlle-Morera; Bradley Doble; James Woodgett; Philip Cohen; Austin Smith
Journal:  Nature       Date:  2008-05-22       Impact factor: 49.962
  9 in total
  6 in total

1.  How does Viagra protect the ischemic heart?

Authors:  Yong Xia
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-04-03       Impact factor: 4.733

2.  Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo.

Authors:  Kathleen C Woulfe; Erhe Gao; Hind Lal; David Harris; Qian Fan; Ronald Vagnozzi; Morgan DeCaul; Xiying Shang; Satish Patel; James R Woodgett; Thomas Force; Jibin Zhou
Journal:  Circ Res       Date:  2010-04-01       Impact factor: 17.367

3.  GSK-3 is a master regulator of neural progenitor homeostasis.

Authors:  Woo-Yang Kim; Xinshuo Wang; Yaohong Wu; Bradley W Doble; Satish Patel; James R Woodgett; William D Snider
Journal:  Nat Neurosci       Date:  2009-10-04       Impact factor: 24.884

4.  Functions of GSK-3 Signaling in Development of the Nervous System.

Authors:  Woo-Yang Kim; William D Snider
Journal:  Front Mol Neurosci       Date:  2011-11-17       Impact factor: 5.639

5.  Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure.

Authors:  Firdos Ahmad; Hind Lal; Jibin Zhou; Ronald J Vagnozzi; Justine E Yu; Xiying Shang; James R Woodgett; Erhe Gao; Thomas Force
Journal:  J Am Coll Cardiol       Date:  2014-08-19       Impact factor: 27.203

Review 6.  GSK-3 as potential target for therapeutic intervention in cancer.

Authors:  James A McCubrey; Linda S Steelman; Fred E Bertrand; Nicole M Davis; Melissa Sokolosky; Steve L Abrams; Giuseppe Montalto; Antonino B D'Assoro; Massimo Libra; Ferdinando Nicoletti; Roberta Maestro; Jorg Basecke; Dariusz Rakus; Agnieszka Gizak; Zoya N Demidenko; Lucio Cocco; Alberto M Martelli; Melchiorre Cervello
Journal:  Oncotarget       Date:  2014-05-30
  6 in total

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