Literature DB >> 19199815

Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.

Simon M N Efange1, Reto Brun, Sergio Wittlin, Joseph D Connolly, Thomas R Hoye, Thomas McAkam, Felix L Makolo, James A Mbah, Dorian P Nelson, Kennedy D Nyongbela, Clare K Wirmum.   

Abstract

Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.

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Year:  2009        PMID： 19199815      PMCID： PMC2765531          DOI： 10.1021/np800338p

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Naturally occurring peroxides with biological activities.

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Review 2.  Peroxy natural products.

Authors:  D A Casteel
Journal:  Nat Prod Rep       Date:  1992-08       Impact factor: 13.423

Review 3.  Antiplasmodial marine natural products in the perspective of current chemotherapy and prevention of malaria: a review.

Authors:  Dominique Laurent; Francesco Pietra
Journal:  Mar Biotechnol (NY)       Date:  2006-03-30       Impact factor: 3.619

4.  A new route to diastereomerically pure cyclopropanes utilizing stabilized phosphorus ylides and gamma-hydroxy enones derived from 1, 2-dioxines: mechanistic investigations and scope of reaction

Authors: 
Journal:  J Org Chem       Date:  2000-09-08       Impact factor: 4.354

5.  Identification of an antimalarial synthetic trioxolane drug development candidate.

Authors:  Jonathan L Vennerstrom; Sarah Arbe-Barnes; Reto Brun; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Arnulf Dorn; Daniel Hunziker; Hugues Matile; Kylie McIntosh; Maniyan Padmanilayam; Josefina Santo Tomas; Christian Scheurer; Bernard Scorneaux; Yuanqing Tang; Heinrich Urwyler; Sergio Wittlin; William N Charman
Journal:  Nature       Date:  2004-08-19       Impact factor: 49.962

6.  Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.

Authors:  Gary H Posner; Paul M O'Neill
Journal:  Acc Chem Res       Date:  2004-06       Impact factor: 22.384

7.  Convergent enantioselective synthesis of the tricyclic core of phomactin A.

Authors:  Peter J Mohr; Randall L Halcomb
Journal:  Org Lett       Date:  2002-07-11       Impact factor: 6.005

8.  Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.

Authors:  Thomas R Hoye; Christopher S Jeffrey; Feng Shao
Journal:  Nat Protoc       Date:  2007       Impact factor: 13.491

9.  Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors:  R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191
  9 in total
  7 in total

Review 1.  Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens.

Authors:  Ramesh Subramani; Mathivanan Narayanasamy; Klaus-D Feussner
Journal:  3 Biotech       Date:  2017-06-29       Impact factor: 2.406

2.  Antimalarial Natural Products.

Authors:  David G I Kingston; Maria Belen Cassera
Journal:  Prog Chem Org Nat Prod       Date:  2022

3.  Bioassay-guided discovery of antibacterial agents: in vitro screening of Peperomia vulcanica, Peperomia fernandopoioana and Scleria striatinux.

Authors:  James A Mbah; Moses N Ngemenya; Ashime Louis Abawah; Smith B Babiaka; Lina N Nubed; Kennedy D Nyongbela; Njimoh Dieudonne Lemuh; Simon M N Efange
Journal:  Ann Clin Microbiol Antimicrob       Date:  2012-05-01       Impact factor: 3.944

Review 4.  The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.

Authors:  Pascal Amoa Onguéné; Fidele Ntie-Kang; Lydia Likowo Lifongo; Jean Claude Ndom; Wolfgang Sippl; Luc Meva'a Mbaze
Journal:  Malar J       Date:  2013-12-13       Impact factor: 2.979

5.  In vitro antiplasmodial activity and prophylactic potentials of extract and fractions of Trema orientalis (Linn.) stem bark.

Authors:  John Oludele Olanlokun; Oluwole Moses David; Anthony Jide Afolayan
Journal:  BMC Complement Altern Med       Date:  2017-08-15       Impact factor: 3.659

6.  Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment.

Authors:  Kennedy D Nyongbela; Fidele Ntie-Kang; Thomas R Hoye; Simon M N Efange
Journal:  Nat Prod Bioprospect       Date:  2017-04-18

Review 7.  Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products.

Authors:  Ronan Batista; Ademir de Jesus Silva; Alaíde Braga de Oliveira
Journal:  Molecules       Date:  2009-08-13       Impact factor: 4.411
  7 in total

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