Literature DB >> 19198633

Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937.

Claudia Hohmann1, Kathrin Schneider, Christina Bruntner, Elisabeth Irran, Graeme Nicholson, Alan T Bull, Amanda L Jones, Roselyn Brown, James E M Stach, Michael Goodfellow, Winfried Beil, Marco Krämer, Johannes F Imhoff, Roderich D Süssmuth, Hans-Peter Fiedler.   

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.

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Year:  2009        PMID： 19198633     DOI： 10.1038/ja.2008.24

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  25 in total

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Review 5.  Antitumor compounds from marine actinomycetes.

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Review 9.  Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action.

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Journal:  Mar Drugs       Date:  2013-07-16       Impact factor: 5.118

10.  Draft Genome Sequence of Marine Actinomycete Streptomyces sp. Strain NTK 937, Producer of the Benzoxazole Antibiotic Caboxamycin.

Authors:  Carlos Olano; Carolina Cano-Prieto; Armando A Losada; Alan T Bull; Michael Goodfellow; Hans-Peter Fiedler; Carmen Méndez; José A Salas
Journal:  Genome Announc       Date:  2014-07-03
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