Literature DB >> 19198611

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

David-Alexandre Trégouët1, Inke R König, Jeanette Erdmann, Alexandru Munteanu, Peter S Braund, Alistair S Hall, Anika Grosshennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain, Thomas Meitinger, Ben J Wright, Michael Preuss, Anthony J Balmforth, Stephen G Ball, Christa Meisinger, Cécile Germain, Alun Evans, Dominique Arveiler, Gérald Luc, Jean-Bernard Ruidavets, Caroline Morrison, Pim van der Harst, Stefan Schreiber, Katharina Neureuther, Arne Schäfer, Peter Bugert, Nour E El Mokhtari, Jürgen Schrezenmeir, Klaus Stark, Diana Rubin, H-Erich Wichmann, Christian Hengstenberg, Willem Ouwehand, Andreas Ziegler, Laurence Tiret, John R Thompson, Francois Cambien, Heribert Schunkert, Nilesh J Samani.   

Abstract

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

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Year:  2009        PMID： 19198611     DOI： 10.1038/ng.314

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


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