Cu(II)-hydrotalcite as an efficient heterogeneous catalyst for Huisgen [3+2] cycloaddition.

Top Cat! Cu(II)-hydrotalcite (HT) is used as a catalyst for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles by [3+2] cycloaddition of various azides and alkynes. The catalyst enjoys advantages such as faster reactivity, good stability, reusability, high catalytic activity without any additives at room temperature, and does not require a nitrogen atmosphere for this "click-chemistry" transformation.