OBJECTIVE: To establish, among the cut-off values for the homeostatic model assessment for insulin resistance index (HOMA-IR) cited in the literature, the best in identifying metabolic syndrome (MS) in obese and overweight children. METHODS: A total of 106 pre-pubertal children were studied. The definition of MS was adapted from that of the International Diabetes Federation. For each cut-off values for HOMA-IR, it was estimated sensibility and specificity for MS. A receiver operating characteristic (ROC) curve was generated using these values. RESULTS: The study included 106 obese (37 girls and 69 boys) and 34 overweight (19 girls and 15 boys) children aged 6,5 +/- 2,3 years. The accuracy of the ROC curve was 72%, and the best cut-off value for HOMAIR was 2,5, with sensitivity of 61% and specificity of 74%. CONCLUSIONS: HOMA-IR may be useful to detect MS and the cut-off 2,5 seems to be the best in obese and overweight pre-pubertal children.
OBJECTIVE: To establish, among the cut-off values for the homeostatic model assessment for insulin resistance index (HOMA-IR) cited in the literature, the best in identifying metabolic syndrome (MS) in obese and overweight children. METHODS: A total of 106 pre-pubertal children were studied. The definition of MS was adapted from that of the International Diabetes Federation. For each cut-off values for HOMA-IR, it was estimated sensibility and specificity for MS. A receiver operating characteristic (ROC) curve was generated using these values. RESULTS: The study included 106 obese (37 girls and 69 boys) and 34 overweight (19 girls and 15 boys) children aged 6,5 +/- 2,3 years. The accuracy of the ROC curve was 72%, and the best cut-off value for HOMAIR was 2,5, with sensitivity of 61% and specificity of 74%. CONCLUSIONS: HOMA-IR may be useful to detect MS and the cut-off 2,5 seems to be the best in obese and overweight pre-pubertal children.
Authors: Daniel Ferraz de Campos Mazo; Rejane Mattar; José Tadeu Stefano; Joyce Matie Kinoshita da Silva-Etto; Márcio Augusto Diniz; Sebastião Mauro Bezerra Duarte; Fabíola Rabelo; Rodrigo Vieira Costa Lima; Priscila Brizolla de Campos; Flair José Carrilho; Claudia P Oliveira Journal: World J Hepatol Date: 2016-08-28
Authors: A D Genazzani; K Shefer; D Della Casa; A Prati; A Napolitano; A Manzo; G Despini; T Simoncini Journal: J Endocrinol Invest Date: 2017-10-31 Impact factor: 4.256
Authors: Ana Elisa M Rinaldi; Gustavo D Pimentel; Avany F Pereira; Gleice Fcp Gabriel; Fernando Moreto; Roberto C Burini Journal: Diabetol Metab Syndr Date: 2010-06-09 Impact factor: 3.320
Authors: Ana Paula Pereira Castro; Ana Paula Carlos Cândido; Roney Luiz de Carvalho Nicolato; Ivo Santana Caldas; George Luiz Lins Machado-Coelho Journal: Eur J Nutr Date: 2013-06-14 Impact factor: 5.614