Literature DB >> 19196509

FR290581, a novel sordarin derivative: synthesis and antifungal activity.

Tadaatsu Hanadate1, Masaki Tomishima, Nobuyuki Shiraishi, Daisuke Tanabe, Hiroshi Morikawa, David Barrett, Satoru Matsumoto, Kazumi Ohtomo, Katsuyuki Maki.   

Abstract

Sordarin is a unique natural product antifungal agent that is an inhibitor of elongation factor 2. To improve biological activity, we synthesized various compounds by novel modification of the aglycone, sordaricin. As a result, we have discovered the novel sordarin derivative FR290581. This compound exhibited superior activity and a good pharmacokinetic profile, and also displayed good in vivo activity against Candida albicans.

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Year:  2009        PMID： 19196509     DOI： 10.1016/j.bmcl.2009.01.051

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

Review 1.  An insight into the antifungal pipeline: selected new molecules and beyond.

Authors:  Luis Ostrosky-Zeichner; Arturo Casadevall; John N Galgiani; Frank C Odds; John H Rex
Journal:  Nat Rev Drug Discov       Date:  2010-08-20       Impact factor: 84.694

Review 2.  The antifungal pipeline: a reality check.

Authors:  John R Perfect
Journal:  Nat Rev Drug Discov       Date:  2017-05-12       Impact factor: 84.694

3.  Identification and characterization of a novel family of selective antifungal compounds (CANBEFs) that interfere with fungal protein synthesis.

Authors:  Gabriel Mircus; Nathaniel Albert; Dafna Ben-Yaakov; Dodo Chikvashvili; Yona Shadkchan; Dimitrios P Kontoyiannis; Nir Osherov
Journal:  Antimicrob Agents Chemother       Date:  2015-07-06       Impact factor: 5.191

4.  Discovery and characterization of a terpene biosynthetic pathway featuring a norbornene-forming Diels-Alderase.

Authors:  Zuodong Sun; Cooper S Jamieson; Masao Ohashi; K N Houk; Yi Tang
Journal:  Nat Commun       Date:  2022-05-11       Impact factor: 17.694

5.  Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.

Authors:  Fumitaka Kudo; Yasunori Matsuura; Takaaki Hayashi; Masayuki Fukushima; Tadashi Eguchi
Journal:  J Antibiot (Tokyo)       Date:  2016-04-13       Impact factor: 2.649

Review 6.  Early state research on antifungal natural products.

Authors:  Melyssa Negri; Tânia P Salci; Cristiane S Shinobu-Mesquita; Isis R G Capoci; Terezinha I E Svidzinski; Erika Seki Kioshima
Journal:  Molecules       Date:  2014-03-07       Impact factor: 4.411

7.  Optimization of zofimarin production by an endophytic fungus, Xylaria sp. Acra L38.

Authors:  Jirapan Chaichanan; Suthep Wiyakrutta; Thunyarat Pongtharangkul; Duangnate Isarangkul; Vithaya Meevootisom
Journal:  Braz J Microbiol       Date:  2014-05-19       Impact factor: 2.476

Review 8.  Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010-2020).

Authors:  Fa-Lei Zhang; Tao Feng
Journal:  J Fungi (Basel)       Date:  2022-02-28
  8 in total

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