| Literature DB >> 19196166 |
Alan R Katritzky1, Danniebelle N Haase, Jodie V Johnson, Alfred Chung.
Abstract
Microwave-assisted solid-phase syntheses of six "difficult" peptides, H-VVSVV-NH(2) (3), H-VVVSVV-NH(2) (4), H-VIVIG-OH (5), H-TVTVTV-NH(2) (6), H-VKDGYI-NH(2) (7), and H-VKDVYI-NH(2) (8), were achieved utilizing N-(Fmoc-alpha-aminoacyl)benzotriazoles. Extension to the syntheses of Leu-enkephalin (9) and amyloid-beta (34-42) (10) demonstrates that this strategy comprises an efficient route to new and known "difficult" peptides.Entities:
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Year: 2009 PMID： 19196166 DOI： 10.1021/jo8026214
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354