| Literature DB >> 19195701 |
B D Hock1, L J Fernyhough, S M Gough, A Steinkasserer, A G Cox, J L McKenzie.
Abstract
Soluble CD83 (sCD83), a potent immunosuppressive agent, circulates at elevated levels in some chronic lymphocytic leukemia (CLL) patients. We report that CLL patients with elevated plasma sCD83 levels had significantly shorter (P=0.038) treatment free survival. Culture of CLL cells with solid phase CD83 mAb+IL-4 significantly increases sCD83 release (23-117-fold, P=0.013) and ligation of normal donor PBMC with solid phase CD83 mAb alone induces similar significant increases in sCD83 release (P=0.003). RT-PCR analysis detected the presence of a transcript for sCD83 in 2/3 CLL samples. These results suggest sCD83 release may play a regulatory role in CLL progression.Entities:
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Year: 2009 PMID： 19195701 DOI： 10.1016/j.leukres.2009.01.001
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156