Literature DB >> 19194034

A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6.

Jun-Ya Ueda1, Shuhei Chijiwa, Motoki Takagi, Kazuo Shin-Ya.   

Abstract

A novel versipelostatin (1) analogue, versipelostatin F (2) was isolated from Streptomyces versipellis 4083-SVS6. The structure of 2 was determined by the analyses of the spectroscopic data. Compound 2 inhibited the expression of GRP78 induced by 2-deoxyglucose with an IC(50) value of 0.3 muM, which is 10-times more potent compared with that of 1.

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Year:  2008        PMID： 19194034     DOI： 10.1038/ja.2008.89

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

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Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
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Review 2.  Natural [4 + 2]-Cyclases.

Authors:  Byung-Sun Jeon; Shao-An Wang; Mark W Ruszczycky; Hung-Wen Liu
Journal:  Chem Rev       Date:  2016-12-01       Impact factor: 60.622

Review 3.  Spirotetronate polyketides as leads in drug discovery.

Authors:  Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  J Nat Prod       Date:  2014-12-01       Impact factor: 4.050

4.  Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides.

Authors:  Takuya Hashimoto; Junko Hashimoto; Kuniko Teruya; Takashi Hirano; Kazuo Shin-ya; Haruo Ikeda; Hung-wen Liu; Makoto Nishiyama; Tomohisa Kuzuyama
Journal:  J Am Chem Soc       Date:  2015-01-05       Impact factor: 15.419
  4 in total

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