Literature DB >> 19193857

Efficient gene therapy-based method for the delivery of therapeutics to primate cortex.

Adrian P Kells1, Piotr Hadaczek, Dali Yin, John Bringas, Vanja Varenika, John Forsayeth, Krystof S Bankiewicz.   

Abstract

Transduction of the primate cortex with adeno-associated virus (AAV)-based gene therapy vectors has been challenging, because of the large size of the cortex. We report that a single infusion of AAV2 vector into thalamus results in widespread expression of transgene in the cortex through transduction of widely dispersed thalamocortical projections. This finding has important implications for the treatment of certain genetic and neurodegenerative diseases.

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Year:  2009        PMID： 19193857      PMCID： PMC2650169          DOI： 10.1073/pnas.0810682106

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  41 in total

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Journal:  J Neurosci       Date:  2003-08-13       Impact factor: 6.167

5.  Basic fibroblast growth factor enhances transduction, distribution, and axonal transport of adeno-associated virus type 2 vector in rat brain.

Authors:  Piotr Hadaczek; Hanna Mirek; John Bringas; Janet Cunningham; Krys Bankiewicz
Journal:  Hum Gene Ther       Date:  2004-05       Impact factor: 5.695

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Journal:  Neurobiol Dis       Date:  2003-12       Impact factor: 5.996

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Journal:  Cancer Res       Date:  2004-04-01       Impact factor: 12.701

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Journal:  Science       Date:  2003-08-08       Impact factor: 47.728
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  64 in total

1.  Enhanced long-term transduction and multilineage engraftment of human hematopoietic stem cells transduced with tyrosine-modified recombinant adeno-associated virus serotype 2.

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Journal:  Hum Gene Ther       Date:  2010-09       Impact factor: 5.695

2.  Correction of brain oligodendrocytes by AAVrh.10 intracerebral gene therapy in metachromatic leukodystrophy mice.

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Journal:  Hum Gene Ther       Date:  2012-07-23       Impact factor: 5.695

3.  Moving toward a gene therapy for Huntington's disease.

Authors:  J C Glorioso; J B Cohen; D L Carlisle; I Munoz-Sanjuan; R M Friedlander
Journal:  Gene Ther       Date:  2015-12       Impact factor: 5.250

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Authors:  Aravind Asokan; David V Schaffer; R Jude Samulski
Journal:  Mol Ther       Date:  2012-01-24       Impact factor: 11.454

Review 5.  Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges.

Authors:  Federico Mingozzi; Katherine A High
Journal:  Nat Rev Genet       Date:  2011-05       Impact factor: 53.242

Review 6.  Gene therapy for misfolding protein diseases of the central nervous system.

Authors:  Waldy San Sebastian; Lluis Samaranch; Adrian P Kells; John Forsayeth; Krystof S Bankiewicz
Journal:  Neurotherapeutics       Date:  2013-07       Impact factor: 7.620

Review 7.  Glial-derived neurotrophic factor gene transfer for Parkinson's disease: anterograde distribution of AAV2 vectors in the primate brain.

Authors:  Adrian P Kells; John Forsayeth; Krystof S Bankiewicz
Journal:  Neurobiol Dis       Date:  2011-10-14       Impact factor: 5.996

Review 8.  Viral vectors for therapy of neurologic diseases.

Authors:  Sourav R Choudhury; Eloise Hudry; Casey A Maguire; Miguel Sena-Esteves; Xandra O Breakefield; Paola Grandi
Journal:  Neuropharmacology       Date:  2016-02-21       Impact factor: 5.250

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Authors:  Mark A Kay
Journal:  Nat Rev Genet       Date:  2011-04-06       Impact factor: 53.242

10.  Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain.

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Journal:  Mol Ther       Date:  2009-12-15       Impact factor: 11.454
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