Literature DB >> 19193851

Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery.

Christopher T Walsh1, Michael A Fischbach.   

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Year:  2009        PMID: 19193851      PMCID: PMC2644097          DOI: 10.1073/pnas.0813405106

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


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2.  Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.

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Journal:  Nat Rev Drug Discov       Date:  2006-12-08       Impact factor: 84.694

4.  ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.

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5.  Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

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9.  A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore.

Authors:  J Richard Miller; Steve Dunham; Igor Mochalkin; Craig Banotai; Matthew Bowman; Susan Buist; Bill Dunkle; Debra Hanna; H James Harwood; Michael D Huband; Alla Karnovsky; Michael Kuhn; Chris Limberakis; Jia Y Liu; Shawn Mehrens; W Thomas Mueller; Lakshmi Narasimhan; Adam Ogden; Jeff Ohren; J V N Vara Prasad; John A Shelly; Laura Skerlos; Mark Sulavik; V Hayden Thomas; Steve VanderRoest; LiAnn Wang; Zhigang Wang; Amy Whitton; Tong Zhu; C Kendall Stover
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3.  Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.

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Review 4.  The Future of Antifungal Drug Therapy: Novel Compounds and Targets.

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5.  N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry.

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6.  Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules.

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10.  Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models.

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