OBJECTIVES: To assess whether a normal-calcium, low-animal protein, low-salt diet is effective in reducing hyperoxaluria in idiopathic calcium oxalate nephrolithiasis compared with a traditional low-oxalate diet, routinely recommended by clinicians METHODS: We treated 56 patients with idiopathic calcium oxalate stone formation who presented with mild hyperoxaluria (>40 mg/d) while consuming afree diet with a normal-calcium, low-animal protein, low-salt diet for a 3-month period. We compared the results obtained with this diet with those of a historical control group of 20 hyperoxaluric patients treated in the traditional way with a low-oxalate diet RESULTS: After 3 months of therapy, the mean oxaluria level had decreased from 50.2 to 35.5 mg/d with the normal-calcium, low-animal protein, low-salt diet and from 45.9 to 40.2 mg/d with the traditional diet (adjusted difference between post-treatment mean value -7.3 mg/d, 95% confidence interval -12.3 to -2.2, P = .005) CONCLUSIONS: The results suggest that a normal-calcium, low-animal protein, low-salt diet can reduce oxalate excretion in hyperoxaluric patients. This should encourage the undertaking of a randomized-control study to confer more solid evidence in support of our findings.
RCT Entities:
OBJECTIVES: To assess whether a normal-calcium, low-animal protein, low-salt diet is effective in reducing hyperoxaluria in idiopathic calcium oxalatenephrolithiasis compared with a traditional low-oxalate diet, routinely recommended by clinicians METHODS: We treated 56 patients with idiopathic calcium oxalate stone formation who presented with mild hyperoxaluria (>40 mg/d) while consuming a free diet with a normal-calcium, low-animal protein, low-salt diet for a 3-month period. We compared the results obtained with this diet with those of a historical control group of 20 hyperoxaluric patients treated in the traditional way with a low-oxalate diet RESULTS: After 3 months of therapy, the mean oxaluria level had decreased from 50.2 to 35.5 mg/d with the normal-calcium, low-animal protein, low-salt diet and from 45.9 to 40.2 mg/d with the traditional diet (adjusted difference between post-treatment mean value -7.3 mg/d, 95% confidence interval -12.3 to -2.2, P = .005) CONCLUSIONS: The results suggest that a normal-calcium, low-animal protein, low-salt diet can reduce oxalate excretion in hyperoxaluricpatients. This should encourage the undertaking of a randomized-control study to confer more solid evidence in support of our findings.
Authors: John C Lieske; William J Tremaine; Claudio De Simone; Helen M O'Connor; Xujian Li; Eric J Bergstralh; David S Goldfarb Journal: Kidney Int Date: 2010-08-25 Impact factor: 10.612
Authors: Robert H Glew; Yijuan Sun; Bruce L Horowitz; Konstantin N Konstantinov; Marc Barry; Joanna R Fair; Larry Massie; Antonios H Tzamaloukas Journal: World J Nephrol Date: 2014-11-06