| Literature DB >> 19193060 |
Johan Neyts1, Erik De Clercq, Raghunath Singha, Yung Hsiung Chang, Asish R Das, Subhasish K Chakraborty, Shih Ching Hong, Shwu-Chen Tsay, Ming-Hua Hsu, Jih Ru Hwu.
Abstract
For establishment of the structure-activity relationship, 19 heterobicycle-coumarin conjugated compounds with the -SCH(2)- linker were synthesized and found to possess significant antiviral activities. Prominent examples included imidazopyridine-coumarin 12c, purine-coumarin 12d, and benzoxazole-coumarin 14c, which inhibited HCV replication at an EC(50) of 6.8, 2.0, and 12 microM, respectively. The heteroatoms in bicycles and the substituent effect on coumarin played essential roles.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19193060 DOI： 10.1021/jm801240d
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446