Yan Zeng1, Xue-Feng Wang, Tao Lin. 1. Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Abstract
OBJECTIVE: To study the protein expression of adenylate kinases (AK)-2 in the brain tissues of patients with drug-refractory temporal epilepsy and the clinical value thereof. METHODS: Specimens of brain from 40 patients with refractory temporal epilepsy, and 20 sex- and age-matched persons with brain trauma. Immunohistochemistry and immunofluorescence examination were used to test the levels of AK2. RESULTS: AK2 was expressed in the temporal lobes and hippocampuses of all epileptics, mainly in the cell bodies, and not in the brain tissues of the controls. CONCLUSION: The overexpression of AK2 may be involved in the pathogenesis of drug-refractory epilepsy and become an important symbol thereof.
OBJECTIVE: To study the protein expression of adenylate kinases (AK)-2 in the brain tissues of patients with drug-refractory temporal epilepsy and the clinical value thereof. METHODS: Specimens of brain from 40 patients with refractory temporal epilepsy, and 20 sex- and age-matched persons with brain trauma. Immunohistochemistry and immunofluorescence examination were used to test the levels of AK2. RESULTS:AK2 was expressed in the temporal lobes and hippocampuses of all epileptics, mainly in the cell bodies, and not in the brain tissues of the controls. CONCLUSION: The overexpression of AK2 may be involved in the pathogenesis of drug-refractory epilepsy and become an important symbol thereof.