Literature DB >> 19191585

Antagonists of the P2X(7) receptor. From lead identification to drug development.

Simon D Guile1, Lilian Alcaraz, Timothy N Birkinshaw, Keith C Bowers, Mark R Ebden, Mark Furber, Michael J Stocks.   

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Year:  2009        PMID： 19191585     DOI： 10.1021/jm801528x

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  37 in total

1.  P2X receptor antagonists for pain management: examination of binding and physicochemical properties.

Authors:  Rebecca J Gum; Brian Wakefield; Michael F Jarvis
Journal:  Purinergic Signal       Date:  2011-11-16       Impact factor: 3.765

Review 2.  Molecular and functional properties of P2X receptors--recent progress and persisting challenges.

Authors:  Karina Kaczmarek-Hájek; Eva Lörinczi; Ralf Hausmann; Annette Nicke
Journal:  Purinergic Signal       Date:  2012-05-01       Impact factor: 3.765

3.  Estrogen and P2 Purinergic Receptor Systems in Microglia: Therapeutic Targets for Neuroprotection.

Authors:  Jessica M Crain; Jyoti J Watters
Journal:  Open Drug Discov J       Date:  2010-01-01

4.  Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567.

Authors:  Anindya Bhattacharya; Qi Wang; Hong Ao; James R Shoblock; Brian Lord; Leah Aluisio; Ian Fraser; Diane Nepomuceno; Robert A Neff; Natalie Welty; Timothy W Lovenberg; Pascal Bonaventure; Alan D Wickenden; Michael A Letavic
Journal:  Br J Pharmacol       Date:  2013-10       Impact factor: 8.739

Review 5.  Activation and regulation of purinergic P2X receptor channels.

Authors:  Claudio Coddou; Zonghe Yan; Tomas Obsil; J Pablo Huidobro-Toro; Stanko S Stojilkovic
Journal:  Pharmacol Rev       Date:  2011-07-07       Impact factor: 25.468

Review 6.  P2X receptors as drug targets.

Authors:  R Alan North; Michael F Jarvis
Journal:  Mol Pharmacol       Date:  2012-12-19       Impact factor: 4.436

Review 7.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

8.  Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach.

Authors:  Claudia Mugnaini; Stefania Nocerino; Valentina Pedani; Serena Pasquini; Andrea Tafi; Maria De Chiaro; Luca Bellucci; Massimo Valoti; Francesca Guida; Livio Luongo; Stefania Dragoni; Alessia Ligresti; Avraham Rosenberg; Daniele Bolognini; Maria Grazia Cascio; Roger G Pertwee; Ruin Moaddel; Sabatino Maione; Vincenzo Di Marzo; Federico Corelli
Journal:  ChemMedChem       Date:  2012-03-02       Impact factor: 3.466

9.  Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists.

Authors:  Michael A Letavic; Brian Lord; Francois Bischoff; Natalie A Hawryluk; Serge Pieters; Jason C Rech; Zachary Sales; Adriana I Velter; Hong Ao; Pascal Bonaventure; Victor Contreras; Xiaohui Jiang; Kirsten L Morton; Brian Scott; Qi Wang; Alan D Wickenden; Nicholas I Carruthers; Anindya Bhattacharya
Journal:  ACS Med Chem Lett       Date:  2013-03-12       Impact factor: 4.345

Review 10.  Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks.

Authors:  Stefanie M A Willekens; Donatienne Van Weehaeghe; Philip Van Damme; Koen Van Laere
Journal:  Eur J Nucl Med Mol Imaging       Date:  2016-12-08       Impact factor: 9.236
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