Literature DB >> 19190979

A new three-way variant t(15;22;17)(q22;q11.2;q21) in acute promyelocytic leukemia.

Takayasu Kato1, Akira Hangaishi1, Motoshi Ichikawa1, Toru Motokura1, Tsuyoshi Takahashi1, Mineo Kurokawa2.   

Abstract

Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report the case of a 44-year-old man with APL carrying a new complex variant translocation (15;22;17). Karyotypic analysis with G-banding of bone marrow cells revealed t(15;22;17) (q22;q11.2;q21). Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed the fusion signals. RT-PCR analysis showed long-form PML/RARA fusion transcripts. A complete remission was attained with a course of conventional chemotherapy with all-trans retinoic acid (ATRA). This is the first report of a new three-way translocation of 22q11 involvement with APL.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19190979     DOI： 10.1007/s12185-008-0253-6

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  31 in total

Review 1.  The pathogenesis of acute promyelocytic leukaemia: evaluation of the role of molecular diagnosis and monitoring in the management of the disease.

Authors:  D Grimwade
Journal:  Br J Haematol       Date:  1999-09       Impact factor: 6.998

2.  Identification of classic and complex t(15;17) and/or RAR alpha/PML gene fusion in APL by cytogenetic and dual color-FISH techniques.

Authors:  H Acar; M Dündar; J Stewart
Journal:  Proc Natl Sci Counc Repub China B       Date:  1997-04

3.  Complex chromosome translocations of standard t(8;21) and t(15;17) arise from a two-step mechanism as evidenced by fluorescence in situ hybridization analysis.

Authors:  G Calabrese; T Min; L Stuppia; R Powles; J G Swansbury; E Morizio; R Peila; E Donti; G Fioritoni; G Palka
Journal:  Cancer Genet Cytogenet       Date:  1996-10-01

4.  Cytogenetic and molecular characterization of a variant translocation associated with acute promyelocytic leukemia and involving chromosomes 11, 15 and 17.

Authors:  L Casula; N Archidiacono; M Grazia Pau; M Addis; R Mura; R Galanello; P Biddau; A Cao; A Nucaro
Journal:  Leukemia       Date:  1996-10       Impact factor: 11.528

5.  Complex translocations involving chromosomes 15 and 17 in acute promyelocytic leukaemia.

Authors:  R Bernstein; B Mendelow; M R Pinto; G Morcom; W Bezwoda
Journal:  Br J Haematol       Date:  1980-10       Impact factor: 6.998

6.  Acute promyelocytic leukemia with t(15;17) and t(2;17;15).

Authors:  O W Bjerrum; P Philip; T Pressler; I Tygstrup
Journal:  Cancer Genet Cytogenet       Date:  1987-09

7.  Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21).

Authors:  C A Tirado; V Golembiewski-Ruiz; J Horvatinovich; J O Moore; P J Buckley; T T Stenzel; B K Goodman
Journal:  Cancer Genet Cytogenet       Date:  2003-08

8.  A complex translocation in acute promyelocytic leukemia.

Authors:  D F Callen; B M Dale; R E Sage; J H Ford
Journal:  Cancer Genet Cytogenet       Date:  1985-03-01

Review 9.  Acute promyelocytic leukemia.

Authors:  R P Warrell; H de Thé; Z Y Wang; L Degos
Journal:  N Engl J Med       Date:  1993-07-15       Impact factor: 91.245

10.  Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17.

Authors:  J Borrow; A D Goddard; D Sheer; E Solomon
Journal:  Science       Date:  1990-09-28       Impact factor: 47.728
View more
  1 in total

1.  Coexistence of t(15;17) and t(15;16;17) detected by fluorescence in situ hybridization in a patient with acute promyelocytic leukemia: A case report and literature review.

Authors:  Rui Zhang; Young-Mi Kim; Xianfu Wang; Yan Li; Hui Pang; Ji-Yun Lee; Shibo Li
Journal:  Oncol Lett       Date:  2014-07-02       Impact factor: 2.967
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.