BACKGROUND: Several studies suggest antidepressant medications can increase prolactin levels. Some, but not all, studies suggest prolactin levels are positively associated with mammographic breast density, an established risk factor for breast cancer. METHODS: We evaluated 29,284 women with two routine screening mammograms 9 to 28 months apart between 1996 to 2006 to examine whether antidepressant use was associated with changes in mammographic breast density. Mammographic breast density was assigned by radiologists and coded according the Breast Imaging Reporting and Data System classification. Exposure to antidepressants was ascertained based on electronic pharmacy dispensing data, including dispensings from claims data. We used polytomous logistic regression to estimate the odds of an increase or decrease in density categories between mammograms associated with antidepressant initiation, continuation, and discontinuation compared with nonusers of any antidepressants. RESULTS: Initiation, continuation, and discontinuation of antidepressant medications were not associated with changes in mammographic density. CONCLUSIONS: The lack of association between antidepressant use and breast density is consistent with recent studies that do not suggest an association between antidepressant use and breast cancer risk.
BACKGROUND: Several studies suggest antidepressant medications can increase prolactin levels. Some, but not all, studies suggest prolactin levels are positively associated with mammographic breast density, an established risk factor for breast cancer. METHODS: We evaluated 29,284 women with two routine screening mammograms 9 to 28 months apart between 1996 to 2006 to examine whether antidepressant use was associated with changes in mammographic breast density. Mammographic breast density was assigned by radiologists and coded according the Breast Imaging Reporting and Data System classification. Exposure to antidepressants was ascertained based on electronic pharmacy dispensing data, including dispensings from claims data. We used polytomous logistic regression to estimate the odds of an increase or decrease in density categories between mammograms associated with antidepressant initiation, continuation, and discontinuation compared with nonusers of any antidepressants. RESULTS: Initiation, continuation, and discontinuation of antidepressant medications were not associated with changes in mammographic density. CONCLUSIONS: The lack of association between antidepressant use and breast density is consistent with recent studies that do not suggest an association between antidepressant use and breast cancer risk.
Authors: Stephen H Taplin; Laura Ichikawa; Diana S M Buist; Deborah Seger; Emily White Journal: Cancer Epidemiol Biomarkers Prev Date: 2004-02 Impact factor: 4.254
Authors: Norman F Boyd; Helen Guo; Lisa J Martin; Limei Sun; Jennifer Stone; Eve Fishell; Roberta A Jong; Greg Hislop; Anna Chiarelli; Salomon Minkin; Martin J Yaffe Journal: N Engl J Med Date: 2007-01-18 Impact factor: 91.245
Authors: Gail A Greendale; Mei-Hua Huang; Giske Ursin; Sue Ingles; Frank Stanczyk; Carolyn Crandall; Gail A Laughlin; Elizabeth Barrett-Connor; Arun Karlamangla Journal: Breast Cancer Res Treat Date: 2007-01-27 Impact factor: 4.872
Authors: Harriet Johansson; Sara Gandini; Bernardo Bonanni; Frederique Mariette; Aliana Guerrieri-Gonzaga; Davide Serrano; Enrico Cassano; Francesca Ramazzotto; Laura Baglietto; Maria Teresa Sandri; Andrea Decensi Journal: Breast Cancer Res Treat Date: 2007-04-28 Impact factor: 4.872