OBJECTIVE: To evaluate whether diffusion-weighted imaging (DWI) is a reliable technique to quantify microstructural differences between head and neck squamous cell carcinomas (SCC) and tumour-free soft tissue. MATERIALS AND METHODS: DWI was obtained from 20 patients with histologically proven, untreated head and neck SCC. DWI was acquired using a diffusion-weighted, navigated echo-planar imaging sequence with a maximum b-value of 800 s/mm2. For an objective assessment of image quality, the signal-to-noise ratio (SNR) was calculated. Microstructural differences between vital tumour tissue and tumour-free soft tissue were quantified by calculating the apparent-diffusion-coefficients (ADC) on a pixel by pixel method. RESULTS: Echo-planar DWI provided good image quality in all patients (mean SNR 18.4). The mean ADC of SCC, (0.64+/-0.28 x 10(-3) mm2/s), was significantly (P<0.0001) lower than that of the tumour-free soft tissue, (2.51+/-0.82 x 10(-3) mm2/s). CONCLUSION: DWI is a reliable diagnostic tool to quantify the microstructural differences between vital tumour tissue and tumour-free soft tissue in patients with head and neck SCC.
OBJECTIVE: To evaluate whether diffusion-weighted imaging (DWI) is a reliable technique to quantify microstructural differences between head and neck squamous cell carcinomas (SCC) and tumour-free soft tissue. MATERIALS AND METHODS: DWI was obtained from 20 patients with histologically proven, untreated head and neck SCC. DWI was acquired using a diffusion-weighted, navigated echo-planar imaging sequence with a maximum b-value of 800 s/mm2. For an objective assessment of image quality, the signal-to-noise ratio (SNR) was calculated. Microstructural differences between vital tumour tissue and tumour-free soft tissue were quantified by calculating the apparent-diffusion-coefficients (ADC) on a pixel by pixel method. RESULTS: Echo-planar DWI provided good image quality in all patients (mean SNR 18.4). The mean ADC of SCC, (0.64+/-0.28 x 10(-3) mm2/s), was significantly (P<0.0001) lower than that of the tumour-free soft tissue, (2.51+/-0.82 x 10(-3) mm2/s). CONCLUSION: DWI is a reliable diagnostic tool to quantify the microstructural differences between vital tumour tissue and tumour-free soft tissue in patients with head and neck SCC.
Authors: Thomas Hauser; Marco Essig; Alexandra Jensen; Lars Gerigk; Frederik Bernd Laun; Marc Münter; Dirk Simon; Bram Stieltjes Journal: Neuroradiology Date: 2013-02-17 Impact factor: 2.804
Authors: Marcelo A Queiroz; Martin Hüllner; Felix Kuhn; Gerhardt Huber; Christian Meerwein; Spyros Kollias; Gustav von Schulthess; Patrick Veit-Haibach Journal: Eur J Nucl Med Mol Imaging Date: 2014-08-05 Impact factor: 9.236
Authors: Julia Fruehwald-Pallamar; Christian Czerny; Marius E Mayerhoefer; Benjamin S Halpern; Christina Eder-Czembirek; Markus Brunner; Matthias Schuetz; Michael Weber; Laura Fruehwald; Andreas M Herneth Journal: Eur J Nucl Med Mol Imaging Date: 2011-04-05 Impact factor: 9.236
Authors: Jing Yuan; David Ka Wai Yeung; Greta S P Mok; Kunwar S Bhatia; Yi-Xiang J Wang; Anil T Ahuja; Ann D King Journal: PLoS One Date: 2014-01-23 Impact factor: 3.240