| Literature DB >> 19188382 |
Mery Ruíz-Cendoya1, Marçal Mariné, M M Rodríguez, Josep Guarro.
Abstract
We have evaluated and compared the efficacies of high doses of amphotericin B (AMB; 3 mg/kg of body weight/day), voriconazole (60 mg/kg), and posaconazole (PSC; 100 mg/kg) alone and combined in a murine model of disseminated infection by Fusarium oxysporum. The combination of AMB with PSC showed the best results, prolonging the survival of mice and reducing their organ fungal loads. This combination might constitute a therapeutic option for those infections where monotherapies fail.Entities:
Mesh:
Substances:
Year: 2009 PMID: 19188382 PMCID: PMC2663119 DOI: 10.1128/AAC.01606-08
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191