| Literature DB >> 19188072 |
Thorsten Laube1, Andreas Bernet, Hans-Martin Dahse, Ilse D Jacobsen, Karlheinz Seifert.
Abstract
Synthesis of protected siphonodictyal C was achieved via drim-7-en-11-al. Some sesquiterpene quinones and hydroquinones were tested for their pharmacological activities in assays in search of antiproliferative, cytotoxic, antiphlogistic, antirheumatic and anti-inflammatory drugs. Wiedendiol B is a ten times stronger cyclooxygenase-2 inhibitor than the reference compound indomethacine. Cyclooxygenase-2 inhibitors are drugs with antiphlogistic and antirheumatic activity.Entities:
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Year: 2009 PMID： 19188072 DOI： 10.1016/j.bmc.2009.01.028
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641