| Literature DB >> 19188065 |
Nian Zhou1, Wayne Zeller, Jun Zhang, Emmanuel Onua, Alex S Kiselyov, Jose Ramirez, Gudrún Palsdottir, Gudrún Halldorsdottir, Thornorkell Andrésson, Mark E Gurney, Jasbir Singh.
Abstract
A series of potent and selective EP(3) receptor antagonists are described. Utilizing a pharmacophore model developed for the EP(3) receptor, a series of 3,4-disubstituted indoles were found to be efficient ligands for this target. These compounds showed high selectivity over IP, FP and other EP receptors. An optimized molecule 7c featured a sound profile and potency in the functional rat and human platelet aggregation assays.Entities:
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Year: 2009 PMID： 19188065 DOI： 10.1016/j.bmcl.2008.12.112
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823