OBJECTIVE: To explore the cost-effectiveness of artesunate against quinine based principally on the findings of a large multi-centre trial carried out in Southeast Asia. METHODS: Trial data were used to compare mortality of patients with severe malaria, treated with eitherartesunate or quinine. This was combined with retrospectively collected cost data to estimate the incremental cost per death averted with the use of artesunate instead of quinine. RESULTS: The incremental cost per death averted using artesunate was approximately 140 USD. Artesunate maintained this high level of cost-effectiveness also when allowing for the uncertainty surrounding the cost and effectiveness assessments. CONCLUSION: This analysis confirms the vast superiority of artesunate for treatment of severe malaria from an economic as well as a clinical perspective.
RCT Entities:
OBJECTIVE: To explore the cost-effectiveness of artesunate against quinine based principally on the findings of a large multi-centre trial carried out in Southeast Asia. METHODS: Trial data were used to compare mortality of patients with severe malaria, treated with either artesunate or quinine. This was combined with retrospectively collected cost data to estimate the incremental cost per death averted with the use of artesunate instead of quinine. RESULTS: The incremental cost per death averted using artesunate was approximately 140 USD. Artesunate maintained this high level of cost-effectiveness also when allowing for the uncertainty surrounding the cost and effectiveness assessments. CONCLUSION: This analysis confirms the vast superiority of artesunate for treatment of severe malaria from an economic as well as a clinical perspective.
Authors: Yoel Lubell; Arthorn Riewpaiboon; Arjen M Dondorp; Lorenz von Seidlein; Olugbenga A Mokuolu; Margaret Nansumba; Samwel Gesase; Alison Kent; George Mtove; Rasaq Olaosebikan; Wirichada Pan Ngum; Caterina I Fanello; Ilse Hendriksen; Nicholas P J Day; Nicholas J White; Shunmay Yeung Journal: Bull World Health Organ Date: 2011-04-28 Impact factor: 9.408
Authors: Wendy A Davis; Philip M Clarke; Peter M Siba; Harin A Karunajeewa; Carol Davy; Ivo Mueller; Timothy M E Davis Journal: Bull World Health Organ Date: 2011-02-01 Impact factor: 9.408
Authors: Arjen M Dondorp; Caterina I Fanello; Ilse C E Hendriksen; Ermelinda Gomes; Amir Seni; Kajal D Chhaganlal; Kalifa Bojang; Rasaq Olaosebikan; Nkechinyere Anunobi; Kathryn Maitland; Esther Kivaya; Tsiri Agbenyega; Samuel Blay Nguah; Jennifer Evans; Samwel Gesase; Catherine Kahabuka; George Mtove; Behzad Nadjm; Jacqueline Deen; Juliet Mwanga-Amumpaire; Margaret Nansumba; Corine Karema; Noella Umulisa; Aline Uwimana; Olugbenga A Mokuolu; Olanrewaju T Adedoyin; Wahab B R Johnson; Antoinette K Tshefu; Marie A Onyamboko; Tharisara Sakulthaew; Wirichada Pan Ngum; Kamolrat Silamut; Kasia Stepniewska; Charles J Woodrow; Delia Bethell; Bridget Wills; Martina Oneko; Tim E Peto; Lorenz von Seidlein; Nicholas P J Day; Nicholas J White Journal: Lancet Date: 2010-11-07 Impact factor: 79.321
Authors: Giovanfrancesco Ferrari; Henry M Ntuku; Christian Burri; Antoinette K Tshefu; Stephan Duparc; Pierre Hugo; Didier K Mitembo; Amanda Ross; Philippe L Ngwala; Joseph N Luwawu; Papa N Musafiri; Symphorien E Ngoie; Christian Lengeler Journal: Malar J Date: 2015-05-30 Impact factor: 2.979
Authors: Melinda P Anthony; Jeremy N Burrows; Stephan Duparc; Joerg J Moehrle; Timothy N C Wells Journal: Malar J Date: 2012-09-07 Impact factor: 2.979