Ewan Goligher1, Niall D Ferguson. 1. Interdepartmental Division of Critical Care Medicine, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Abstract
PURPOSE OF REVIEW: To describe the trends in the results of epidemiological studies of mechanical ventilation. RECENT FINDINGS: Changes in population demographics have increased the incidence of mechanical ventilation. Higher age and comorbidity rates portend poorer outcomes of mechanical ventilation. The most common indication for initiation of mechanical ventilation is acute respiratory failure, including postoperative respiratory failure, pneumonia, sepsis, and acute respiratory distress syndrome. Patients with sepsis and acute respiratory distress syndrome have a much higher mortality risk than the rest of this population. Changes over time in the selection of modes of ventilation, tidal volumes, positive end-expiratory pressure levels, weaning strategies, and tracheostomy timing appear to accord with data from randomized controlled trials in the literature. However, despite these changes, observational studies have not detected a statistically significant change in adjusted mortality over time. SUMMARY: The burden of critical illness will likely continue to increase in the future. Evidence from randomized trials appears to have affected the management of mechanical ventilation, but adherence to evidence-based practices may not be ideal.
PURPOSE OF REVIEW: To describe the trends in the results of epidemiological studies of mechanical ventilation. RECENT FINDINGS: Changes in population demographics have increased the incidence of mechanical ventilation. Higher age and comorbidity rates portend poorer outcomes of mechanical ventilation. The most common indication for initiation of mechanical ventilation is acute respiratory failure, including postoperative respiratory failure, pneumonia, sepsis, and acute respiratory distress syndrome. Patients with sepsis and acute respiratory distress syndrome have a much higher mortality risk than the rest of this population. Changes over time in the selection of modes of ventilation, tidal volumes, positive end-expiratory pressure levels, weaning strategies, and tracheostomy timing appear to accord with data from randomized controlled trials in the literature. However, despite these changes, observational studies have not detected a statistically significant change in adjusted mortality over time. SUMMARY: The burden of critical illness will likely continue to increase in the future. Evidence from randomized trials appears to have affected the management of mechanical ventilation, but adherence to evidence-based practices may not be ideal.
Authors: Klemens Horst; Hagen Andruszkow; Christian D Weber; Miguel Pishnamaz; Christian Herren; Qiao Zhi; Matthias Knobe; Rolf Lefering; Frank Hildebrand; Hans-Christoph Pape Journal: PLoS One Date: 2017-10-19 Impact factor: 3.240