| Literature DB >> 19186204 |
J Brenner1, M Bellaiche, E Gross, D Elad, Z Oved, M Haimovitz, A Wasserman, O Friedgut, Y Stram, V Bumbarov, H Yadin.
Abstract
The ultimate goal of a vaccine is to protect vaccinated animals against re-exposure to the same pathogen and provide sterile immunity. However, a cutaneous clinical manifestation appeared, following re-exposure of cattle that had been vaccinated with the RM65 strain, to LSDV infection during an epidemic in 2006-2007. Four thousand six hundred and seven vaccinated cows entered the study after being re-exposed to LSDV infection. Of them, 513 (11%) presented lumps, and there was a marked difference between the proportions of dairy and feedlot animals that were affected: 146 out of 3517 and 367 out of 1090 (6.6 and 33.7%, respectively). This data suggests that the potency of the vaccine need to be re-assessed for beef cattle.Entities:
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Year: 2009 PMID： 19186204 DOI： 10.1016/j.vaccine.2009.01.020
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641