Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes.

Literature DB >> 19185988

Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes.

Ping Zhang¹, Yan Zhang, Li Mao, Zhiyuan Zhang, Wantao Chen.

Abstract

To characterize the biological features of side population (SP) in oral squamous cell carcinoma (OCC), SP and non-SP were sorted and compared. The SP cells were more clonogenic and in nude mice, only 10,000 SP cells were needed for tumor development compared to 1,000,000 non-SP cells. The SP cells expressed higher levels of ABCG2, ABCB1, CD44, Oct-4, Bmi-1, NSPc1 and CK19. The SP cells generated SP and non-SP populations, whereas the non-SP cells generated only non-SP. These findings provide the first evidence that SP in OCC possesses tumor stem cell phenotypes and may play an important role in OCC tumorigenesis.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19185988 DOI： 10.1016/j.canlet.2008.12.015

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

Keyword Cloud
Cited

58 in total

Review 1. The biology of head and neck cancer stem cells.

Authors: Zhaocheng Zhang; Manoel Sant'Ana Filho; Jacques E Nör
Journal: Oral Oncol Date: 2011-11-08 Impact factor: 5.337

Review 2. Head and neck cancer stem cells.

Authors: S Krishnamurthy; J E Nör
Journal: J Dent Res Date: 2011-09-20 Impact factor: 6.116

3. A rare fraction of drug-resistant follicular lymphoma cancer stem cells interacts with follicular dendritic cells to maintain tumourigenic potential.

Authors: Chung-Gi Lee; Bikul Das; Tara L Lin; Chelsea Grimes; Xin Zhang; Tracey Lavezzi; Li Huang; John Cole; Lillian Yau; Li Li
Journal: Br J Haematol Date: 2012-04-18 Impact factor: 6.998

Review 4. Cancer Stem Cells in Squamous Cell Carcinoma.

Authors: Zhe Jian; Alexander Strait; Antonio Jimeno; Xiao-Jing Wang
Journal: J Invest Dermatol Date: 2016-11-24 Impact factor: 8.551

5. Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer.

Authors: Hui Sun Leong; Fui Teen Chong; Pui Hoon Sew; Dawn P Lau; Bernice H Wong; Bin-Tean Teh; Daniel S W Tan; N Gopalakrishna Iyer
Journal: Stem Cells Transl Med Date: 2014-07-14 Impact factor: 6.940

6. Side population cells from long-term passage non-small cell lung cancer cells display loss of cancer stem cell-like properties and chemoradioresistance.

Authors: Hao Gu; Xin-Yu Wu; Rui-Tai Fan; Xin Wang; You-Zhong Guo; Rui Wang
Journal: Oncol Lett Date: 2016-08-02 Impact factor: 2.967

Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes.

Review 1. The biology of head and neck cancer stem cells.

Review 2. Head and neck cancer stem cells.

3. A rare fraction of drug-resistant follicular lymphoma cancer stem cells interacts with follicular dendritic cells to maintain tumourigenic potential.

Review 4. Cancer Stem Cells in Squamous Cell Carcinoma.

5. Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer.

6. Side population cells from long-term passage non-small cell lung cancer cells display loss of cancer stem cell-like properties and chemoradioresistance.

Review 7. Perivascular stem cell niche in head and neck cancer.

8. Cancer stem cell and stromal microenvironment.

9. Cancer stem cells in head and neck squamous cell carcinoma.

10. The cancer stem cell concept in progression of head and neck cancer.