| Literature DB >> 19185489 |
Lupei Du1, Minyong Li, Qian Yang, Yiqun Tang, Qidong You, Lin Xia.
Abstract
The combination of I(Kr) and I(Ks) blockade could lead to synergistic and safe class III anti-arrhythmic effect with the enhanced efficacy and reduced risk. On the rationale of structural hybridization of azimilide and HMR-1556, a novel series of I(Kr) and I(Ks) dual blockers were designed, synthesized and evaluated in vitro. One compound, 3r (CPUY11018), deserves further evaluation for its potent anti-arrhythmic activity and favorable cardiovascular profile.Entities:
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Year: 2009 PMID： 19185489 DOI： 10.1016/j.bmcl.2009.01.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823