BACKGROUND: Impaired production/release of defensins, representative endogenous antimicrobial peptides, is associated with the pathogenesis of inflammatory bowel disease (IBD). MATERIAL AND METHODS: Employing in house radioimmunoassay, we examined concentrations of the major forms alpha-defensins, human neutrophil peptides (HNP) 1-3 and human beta-defensin (HBD)-2 in plasma of 55 IBD patients consisting of 29 patients with ulcerative colitis (UC) and 26 with Crohn's disease (CD) and 57 controls. RESULTS: The circulating HNP 1-3, but not HBD-2, levels in IBD patients were significantly higher than those in controls. Plasma HNP 1-3 concentrations in CD patients significantly correlated with Crohn's disease activity index, peripheral white blood cell counts, serum CRP values and TNF-alpha levels. CONCLUSIONS: Elevation of circulating alpha-defensins levels is suggestive of their physiopathological roles in IBD. Plasma HNP 1-3 concentrations may be an indicator for CD activity and their association with CRP and TNF-alpha supports a possible association with the inflammatory process.
BACKGROUND: Impaired production/release of defensins, representative endogenous antimicrobial peptides, is associated with the pathogenesis of inflammatory bowel disease (IBD). MATERIAL AND METHODS: Employing in house radioimmunoassay, we examined concentrations of the major forms alpha-defensins, humanneutrophil peptides (HNP) 1-3 and humanbeta-defensin (HBD)-2 in plasma of 55 IBD patients consisting of 29 patients with ulcerative colitis (UC) and 26 with Crohn's disease (CD) and 57 controls. RESULTS: The circulating HNP 1-3, but not HBD-2, levels in IBD patients were significantly higher than those in controls. Plasma HNP 1-3 concentrations in CD patients significantly correlated with Crohn's disease activity index, peripheral white blood cell counts, serum CRP values and TNF-alpha levels. CONCLUSIONS: Elevation of circulating alpha-defensins levels is suggestive of their physiopathological roles in IBD. Plasma HNP 1-3 concentrations may be an indicator for CD activity and their association with CRP and TNF-alpha supports a possible association with the inflammatory process.
Authors: E Cerrillo; I Moret; M Iborra; D Ramos; E Busó; L Tortosa; E Sáez-González; P Nos; B Beltrán Journal: Clin Exp Immunol Date: 2018-01-10 Impact factor: 4.330
Authors: Ehab H Mattar; Hussein A Almehdar; Abdullah A AlJaddawi; Isam ElDin M Abu Zeid; Elrashdy M Redwan Journal: J Immunol Res Date: 2016-06-20 Impact factor: 4.818
Authors: John Gubatan; Derek R Holman; Christopher J Puntasecca; Danielle Polevoi; Samuel Js Rubin; Stephan Rogalla Journal: World J Gastroenterol Date: 2021-11-21 Impact factor: 5.742
Authors: R Gacesa; A Vich Vila; V Collij; Z Mujagic; A Kurilshikov; M D Voskuil; E A M Festen; C Wijmenga; D M A E Jonkers; G Dijkstra; J Fu; A Zhernakova; F Imhann; R K Weersma Journal: Gut Microbes Date: 2021 Jan-Dec