OBJECTIVE: To determine the optimal dose, safety, and efficacy of an estrogen receptor beta selective Chinese herbal extract, menopausal formula 101 (MF101), for treating hot flushes. METHODS: A randomized, blinded trial in 217 postmenopausal women with hot flushes randomized to 5 or 10 g/day ofMF101 or placebo for 12 weeks. RESULTS: The effects of 5 g/day of MF101 did not differ from those of placebo. After 12 weeks, the mean percent decrease in frequency of hot flushes in the 10 g/day group was 12.9% greater than that in the placebo group (P = 0.15), the median percent decrease was 11.7% greater than that in the placebo group (P = 0.05), and the proportion of women with at least a 50% reduction in hot flushes was 16.2% greater than that in the placebo group (P = 0.03). CONCLUSIONS: Treatment with 10 g/day of MF101 reduces the frequency of hot flushes. Trials with higher doses are planned.
RCT Entities:
OBJECTIVE: To determine the optimal dose, safety, and efficacy of an estrogen receptor beta selective Chinese herbal extract, menopausal formula 101 (MF101), for treating hot flushes. METHODS: A randomized, blinded trial in 217 postmenopausal women with hot flushes randomized to 5 or 10 g/day of MF101 or placebo for 12 weeks. RESULTS: The effects of 5 g/day of MF101 did not differ from those of placebo. After 12 weeks, the mean percent decrease in frequency of hot flushes in the 10 g/day group was 12.9% greater than that in the placebo group (P = 0.15), the median percent decrease was 11.7% greater than that in the placebo group (P = 0.05), and the proportion of women with at least a 50% reduction in hot flushes was 16.2% greater than that in the placebo group (P = 0.03). CONCLUSIONS: Treatment with 10 g/day of MF101 reduces the frequency of hot flushes. Trials with higher doses are planned.
Authors: Gangadhara R Sareddy; Binoj C Nair; Vijay K Gonugunta; Quan-guang Zhang; Andrew Brenner; Darrell W Brann; Rajeshwar Rao Tekmal; Ratna K Vadlamudi Journal: Mol Cancer Ther Date: 2012-03-21 Impact factor: 6.261
Authors: Lili Zhang; Brigitte E Blackman; Marcus D Schonemann; Tatjana Zogovic-Kapsalis; Xiaoyu Pan; Mary Tagliaferri; Heather A Harris; Isaac Cohen; Renee A Reijo Pera; Synthia H Mellon; Richard I Weiner; Dale C Leitman Journal: PLoS One Date: 2010-07-27 Impact factor: 3.240
Authors: Sreenivasan Paruthiyil; Aleksandra Cvoro; Xiaoyue Zhao; Zhijin Wu; Yunxia Sui; Richard E Staub; Scott Baggett; Candice B Herber; Chandi Griffin; Mary Tagliaferri; Heather A Harris; Isaac Cohen; Leonard F Bjeldanes; Terence P Speed; Fred Schaufele; Dale C Leitman Journal: PLoS One Date: 2009-07-17 Impact factor: 3.240