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Literature DB >> 19182545

Genetic control of programmed cell death (apoptosis) in Drosophila.

Dongbin Xu¹, Sarah E Woodfield, Tom V Lee, Yun Fan, Christian Antonio, Andreas Bergmann.

Abstract

Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2009 PMID： 19182545 PMCID： PMC2702463 DOI： 10.4161/fly.3.1.7800

Source DB: PubMed Journal: Fly (Austin) ISSN： 1933-6934 Impact factor: 2.160

166 in total

1. Cell death in ovarian chambers of Drosophila melanogaster.

Authors: F Giorgi; P Deri
Journal: J Embryol Exp Morphol Date: 1976-06

2. Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila.

Authors: Christian Werz; Tom V Lee; Peter L Lee; Melinda Lackey; Clare Bolduc; David S Stein; Andreas Bergmann
Journal: Development Date: 2005-11-09 Impact factor: 6.868

3. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

Authors: A M Verhagen; P G Ekert; M Pakusch; J Silke; L M Connolly; G E Reid; R L Moritz; R J Simpson; D L Vaux
Journal: Cell Date: 2000-07-07 Impact factor: 41.582

4. Cytochrome c-d regulates developmental apoptosis in the Drosophila retina.

Authors: César S Mendes; Eli Arama; Samara Brown; Heather Scherr; Mayank Srivastava; Andreas Bergmann; Hermann Steller; Bertrand Mollereau
Journal: EMBO Rep Date: 2006-08-11 Impact factor: 8.807

5. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms.

Authors: Soon Ji Yoo; Jun R Huh; Israel Muro; Hong Yu; Lijuan Wang; Susan L Wang; R M Renny Feldman; Rollie J Clem; H-Arno J Müller; Bruce A Hay
Journal: Nat Cell Biol Date: 2002-06 Impact factor: 28.824

6. The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.

Authors: Rebecca Wilson; Lakshmi Goyal; Mark Ditzel; Anna Zachariou; David A Baker; Julie Agapite; Hermann Steller; Pascal Meier
Journal: Nat Cell Biol Date: 2002-06 Impact factor: 28.824

7. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation.

Authors: Y Hu; L Ding; D M Spencer; G Núñez
Journal: J Biol Chem Date: 1998-12-11 Impact factor: 5.157

8. Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila.

Authors: Bonni Laundrie; Jeanne S Peterson; Jason S Baum; Jeffrey C Chang; Dana Fileppo; Sharona R Thompson; Kimberly McCall
Journal: Genetics Date: 2003-12 Impact factor: 4.562

9. Drosophila cbl is essential for control of cell death and cell differentiation during eye development.

Authors: Yuan Wang; Christian Werz; Dongbin Xu; Zhihong Chen; Ying Li; Ernst Hafen; Andreas Bergmann
Journal: PLoS One Date: 2008-01-16 Impact factor: 3.240

10. DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.

Authors: Paulo S Ribeiro; Erina Kuranaga; Tencho Tenev; François Leulier; Masayuki Miura; Pascal Meier
Journal: J Cell Biol Date: 2007-12-31 Impact factor: 10.539

59 in total

9. Evaluation of potential reference genes for real time RT-PCR studies in Atlantic halibut (Hippoglossus Hippoglossus L.); during development, in tissues of healthy and NNV-injected fish, and in anterior kidney leucocytes.

Authors: Aina-Cathrine Øvergård; Audun Helge Nerland; Sonal Patel
Journal: BMC Mol Biol Date: 2010-05-11 Impact factor: 2.946

10. The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila.

Authors: Y Fan; A Bergmann
Journal: Cell Death Differ Date: 2009-12-04 Impact factor: 15.828

Genetic control of programmed cell death (apoptosis) in Drosophila.

1. Cell death in ovarian chambers of Drosophila melanogaster.

2. Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila.

3. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

4. Cytochrome c-d regulates developmental apoptosis in the Drosophila retina.

5. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms.

6. The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.

7. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation.

8. Germline cell death is inhibited by P-element insertions disrupting the dcp-1/pita nested gene pair in Drosophila.

9. Drosophila cbl is essential for control of cell death and cell differentiation during eye development.

10. DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.

1. Drosophila melanogaster: a new model to study cisplatin-induced neurotoxicity.

2. Autophagy can promote but is not required for epithelial cell extrusion in the amnioserosa of the Drosophila embryo.

3. Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.

4. A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells.

Review 5. The role of ubiquitylation for the control of cell death in Drosophila.

6. The unique Morgue ubiquitination protein is conserved in a diverse but restricted set of invertebrates.

7. Detecting caspase activity in Drosophila larval imaginal discs.

8. Multiple mechanisms modulate distinct cellular susceptibilities toward apoptosis in the developing Drosophila eye.

9. Evaluation of potential reference genes for real time RT-PCR studies in Atlantic halibut (Hippoglossus Hippoglossus L.); during development, in tissues of healthy and NNV-injected fish, and in anterior kidney leucocytes.

10. The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila.