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Literature DB >> 19182541

Dissecting the genetics of longevity in Drosophila melanogaster.

Abstract

Drosophila melanogaster has been an historically important system for investigating the genetic basis of longevity, and will continue to be valuable as new technologies permit genomic explorations into the biology of aging. The utility of D. melanogaster resides in two resources: its powerful genetic tools as a model system, and a natural ecology that provides substantial genetic variation across significant environmental heterogeneity. Here we provide a review of the genetics of longevity in D. melanogaster, in which we describe the characterization of individual aging genes, the complexity of the genetic architecture of this quantitative trait, and the evaluation of natural genetic variation in the evolution of life histories.

Entities: Species

Mesh：

Year: 2009 PMID： 19182541 DOI： 10.4161/fly.3.1.7771

Source DB: PubMed Journal: Fly (Austin) ISSN： 1933-6934 Impact factor: 2.160

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Cited

37 in total

1. Pleiotropy of segregating genetic variants that affect honey bee worker life expectancy.

Authors: Luke R Dixon; Michelle R McQuage; Ellen J Lonon; Dominique Buehler; Oumar Seck; Olav Rueppell
Journal: Exp Gerontol Date: 2012-06-01 Impact factor: 4.032

2. Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.

Authors: Joanna R Sutton; Jessica R Blount; Kozeta Libohova; Wei-Ling Tsou; Gnanada S Joshi; Henry L Paulson; Maria do Carmo Costa; K Matthew Scaglione; Sokol V Todi
Journal: Hum Mol Genet Date: 2017-04-15 Impact factor: 6.150

3. Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila.

Authors: A T Branco; L Schilling; K Silkaitis; D K Dowling; B Lemos
Journal: Heredity (Edinb) Date: 2016-10-12 Impact factor: 3.821

4. The many faces of pleiotropy.

Authors: Annalise B Paaby; Matthew V Rockman
Journal: Trends Genet Date: 2012-11-07 Impact factor: 11.639

5. A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-history adaptation.

Authors: Annalise B Paaby; Alan O Bergland; Emily L Behrman; Paul S Schmidt
Journal: Evolution Date: 2014-11-20 Impact factor: 3.694

Dissecting the genetics of longevity in Drosophila melanogaster.

1. Pleiotropy of segregating genetic variants that affect honey bee worker life expectancy.

2. Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.

3. Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila.

4. The many faces of pleiotropy.

5. A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-history adaptation.

6. Fitness differences due to allelic variation at Esterase-4 locus in Drosophila ananassae.

7. An inversion supergene in Drosophila underpins latitudinal clines in survival traits.

8. Preadult life history variation determines adult transcriptome expression.

Review 9. Integrating evolutionary and molecular genetics of aging.

Review 10. Molecular mechanisms of age-related sleep loss in the fruit fly - a mini-review.