BACKGROUND/AIMS: To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer's disease, vascular dementia or both. METHODS: This is an 8-week, multicenter, randomized, double-blind, placebo-controlled trial carried out independently of the pharmaceutical industry. Changes in the agitation and aggression subscore of the Neuropsychiatric Inventory (NPI) were the primary outcomes. The secondary out- comes were the changes in the caregivers' total burden scores (measured by the NPI) and changes in the Brief Agitation Rating Scale (BARS). RESULTS: In total, 103 institutionalized patients at 35 sites were randomized to the trial. After 8 weeks, no statistically significant differences were found between the 2 groups for all outcomes. A trend was observed in favor of the OXC group in the reduction in the scores on the BARS (p = 0.07). CONCLUSION: This study found no significant effect of OXC in treatment of agitation and aggression in patients with dementia. Copyright 2009 S. Karger AG, Basel.
RCT Entities:
BACKGROUND/AIMS: To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer's disease, vascular dementia or both. METHODS: This is an 8-week, multicenter, randomized, double-blind, placebo-controlled trial carried out independently of the pharmaceutical industry. Changes in the agitation and aggression subscore of the Neuropsychiatric Inventory (NPI) were the primary outcomes. The secondary out- comes were the changes in the caregivers' total burden scores (measured by the NPI) and changes in the Brief Agitation Rating Scale (BARS). RESULTS: In total, 103 institutionalized patients at 35 sites were randomized to the trial. After 8 weeks, no statistically significant differences were found between the 2 groups for all outcomes. A trend was observed in favor of the OXC group in the reduction in the scores on the BARS (p = 0.07). CONCLUSION: This study found no significant effect of OXC in treatment of agitation and aggression in patients with dementia. Copyright 2009 S. Karger AG, Basel.
Authors: Paul B Rosenberg; Lea T Drye; Anton P Porsteinsson; Bruce G Pollock; D P Devanand; Constantine Frangakis; Zahinoor Ismail; Christopher Marano; Curtis L Meinert; Jacobo E Mintzer; Cynthia A Munro; Gregory Pelton; Peter V Rabins; Lon S Schneider; David M Shade; Daniel Weintraub; Jeffery Newell; Jerome Yesavage; Constantine G Lyketsos Journal: Int Psychogeriatr Date: 2015-08-25 Impact factor: 3.878
Authors: Mairead M Bartley; Laura Suarez; Reem M A Shafi; Joshua M Baruth; Amanda J M Benarroch; Maria I Lapid Journal: Curr Psychiatry Rep Date: 2018-06-23 Impact factor: 5.285
Authors: Maria Soto; Sandrine Andrieu; Fati Nourhashemi; Pierre Jean Ousset; Clive Ballard; Philippe Robert; Bruno Vellas; Constantine G Lyketsos; Paul B Rosenberg Journal: Int Psychogeriatr Date: 2014-09-16 Impact factor: 3.878
Authors: Benedikt Amann; Johannes Pantel; Heinz Grunze; Eduard Vieta; Francesc Colom; Ana Gonzalez-Pinto; Dieter Naber; Harald Hampel Journal: Clin Pract Epidemiol Ment Health Date: 2009-06-16