| Literature DB >> 19181530 |
Mei Yang1, Jian-Feng Ge, Chika Arai, Isamu Itoh, Qiang Fu, Masataka Ihara.
Abstract
In vivo antimalarial drug candidates screening test was carried out on a series of water-soluble 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives. Among them, 3-(diethylamino)-7-(piperidin-1-yl)phenoxazin-5-ium chloride (SSJ-206) showing highest efficacy was chosen for further pharmcodynamics and pharmacokinetics study. It was supported from these data that the phenoxazinium salts, SSJ-206, would be one of hopeful candidates as an oral antimalarial drug.Entities:
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Year: 2009 PMID： 19181530 DOI： 10.1016/j.bmc.2009.01.021
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641