| Literature DB >> 19181441 |
Zhenbo Zhang1, Lin Jia, Youji Feng, Wenxin Zheng.
Abstract
We previously showed that the expressing level of FSH receptor (FSHR) increased from ovarian epithelial inclusions (OEIs) to benign ovarian epithelial tumors (OETs) and to borderline OETs, whereas FSHR levels decreased with an increase in carcinoma grade. The aim of this study was to investigate the role of FSHR in OET development. MCV152 cells with FSHR overexpression showed an increased cellular proliferation and invasive capacity, which was associated with reduced levels of prohibitin and RII-beta expression and increased levels of HER-2/neu, c-Myc, and EGFR expression. Overexpression of FSHR may be associated with an elevated level of OET cell proliferation via an enhanced activity of potential oncogenic pathways. Therefore, the findings in this study suggest that overexpression of FSHR may play a role in OET development.Entities:
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Year: 2009 PMID： 19181441 DOI： 10.1016/j.canlet.2008.12.024
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679