Literature DB >> 19180572

Characterization of PEDF: a multi-functional serpin family protein.

S Filleur1, T Nelius, W de Riese, R C Kennedy.   

Abstract

Pigment epithelium-derived factor (PEDF) is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties; it balances angiogenesis in the eye and blocks tumor progression. The mechanisms underlying most of these events are not completely clear; however, it appears that PEDF acts via multiple high affinity ligands and cell receptors. In this review article, we will summarize the current knowledge on the biochemical properties of PEDF and its receptors, the multimodal activities of PEDF and finally address the therapeutic potential of PEDF in treating angiogenesis-, neurodegeneration- and inflammation-related diseases.

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Year:  2009        PMID： 19180572     DOI： 10.1002/jcb.22072

Source DB:  PubMed          Journal:  J Cell Biochem        ISSN： 0730-2312            Impact factor:   4.429


  89 in total

1.  Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: implications for antitumor activity.

Authors:  Monika Deshpande; Luigi Notari; Preeti Subramanian; Vicente Notario; S Patricia Becerra
Journal:  Int J Oncol       Date:  2012-04-10       Impact factor: 5.650

Review 2.  Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions.

Authors:  James C Whisstock; Gary A Silverman; Phillip I Bird; Stephen P Bottomley; Dion Kaiserman; Cliff J Luke; Stephen C Pak; Jean-Marc Reichhart; James A Huntington
Journal:  J Biol Chem       Date:  2010-05-24       Impact factor: 5.157

3.  Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization.

Authors:  Kyoungmin Park; Ji Jin; Yang Hu; Kevin Zhou; Jian-xing Ma
Journal:  Am J Pathol       Date:  2011-02       Impact factor: 4.307

Review 4.  Bone biology: insights from osteogenesis imperfecta and related rare fragility syndromes.

Authors:  Roberta Besio; Chi-Wing Chow; Francesca Tonelli; Joan C Marini; Antonella Forlino
Journal:  FEBS J       Date:  2019-07-05       Impact factor: 5.542

5.  PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts.

Authors:  Francesca Nardi; Philip Fitchev; Omar E Franco; Jelena Ivanisevic; Adrian Scheibler; Simon W Hayward; Charles B Brendler; Michael A Welte; Susan E Crawford
Journal:  J Cell Sci       Date:  2018-07-11       Impact factor: 5.285

6.  Assays for the antiangiogenic and neurotrophic serpin pigment epithelium-derived factor.

Authors:  Preeti Subramanian; Susan E Crawford; S Patricia Becerra
Journal:  Methods Enzymol       Date:  2011       Impact factor: 1.600

7.  Expression and purification of functional epitope of pigment epithelium-derived factor in E. coli with inhibiting effect on endothelial cells.

Authors:  Qing Gong; Xia Yang; Weibin Cai; Guoquan Gao; Zhonghan Yang
Journal:  Protein J       Date:  2010-04       Impact factor: 2.371

8.  Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients.

Authors:  Alicia J Jenkins; Dongxu Fu; Madona Azar; Julie A Stoner; Derrick G Kaufman; Sarah Zhang; Richard L Klein; Maria F Lopes-Virella; Jian-Xing Ma; Timothy J Lyons
Journal:  J Diabetes Complications       Date:  2014-01-17       Impact factor: 2.852

9.  Positive correlation between PEDF expression levels and macrophage density in the human prostate.

Authors:  Thomas Nelius; Christina Samathanam; Dalia Martinez-Marin; Natalie Gaines; Jessica Stevens; Johnny Hickson; Werner de Riese; Stéphanie Filleur
Journal:  Prostate       Date:  2012-10-04       Impact factor: 4.104

10.  Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis.

Authors:  Li Jia; David J Waxman
Journal:  Cancer Lett       Date:  2012-12-08       Impact factor: 8.679
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