BACKGROUND: Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. METHODS AND RESULTS: From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). CONCLUSIONS: An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.
BACKGROUND: Aortic pulse wave velocity (PWV) is widely used as a noninvasive index of arterial stiffness and was used in the present study to investigate the relationship between PWV and cardiovascular mortality in the middle-aged and elderly Japanese population using a longitudinal study design. METHODS AND RESULTS: From 1988 to 2003, a total of 3,960 men (50-69 years old at baseline) who underwent medical check-ups and measurement of PWV, which was standardized for diastolic blood pressure, were recruited and divided into 4 groups according to the PWV values. The average follow-up period was 8.2 years. Mortality from all-causes and from cardiovascular disease significantly increased as PWV increased in the entire follow-up period. Multivariate-adjusted relative risks of all-cause and cardiovascular disease mortality for the highest quartile of PWV (>9.0 m/s) were 1.28 (95% confidence interval (CI) 0.97-1.68) and 1.83 (95%CI 1.02-3.29), respectively, compared with the lowest quartile (<7.5 m/s). CONCLUSIONS: An increased PWV can predict cardiovascular mortality in middle-aged and elderly Japanese men.
Authors: N Takashima; T C Turin; K Matsui; N Rumana; Y Nakamura; A Kadota; Y Saito; H Sugihara; Y Morita; M Ichikawa; K Hirose; K Kawakani; N Hamajima; K Miura; H Ueshima; Y Kita Journal: J Hum Hypertens Date: 2013-10-31 Impact factor: 3.012
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Authors: Ji Won Lee; Jin Hur; Young Jin Kim; Hye-Jeong Lee; Ji Eun Nam; Hee-Yeong Kim; Yoo Jin Hong; Seok Min Ko; Tae Hoon Kim; Byoung Wook Choi Journal: PLoS One Date: 2014-04-22 Impact factor: 3.240
Authors: Yoav Ben-Shlomo; Melissa Spears; Chris Boustred; Margaret May; Simon G Anderson; Emelia J Benjamin; Pierre Boutouyrie; James Cameron; Chen-Huan Chen; J Kennedy Cruickshank; Shih-Jen Hwang; Edward G Lakatta; Stephane Laurent; João Maldonado; Gary F Mitchell; Samer S Najjar; Anne B Newman; Mitsuru Ohishi; Bruno Pannier; Telmo Pereira; Ramachandran S Vasan; Tomoki Shokawa; Kim Sutton-Tyrell; Francis Verbeke; Kang-Ling Wang; David J Webb; Tine Willum Hansen; Sophia Zoungas; Carmel M McEniery; John R Cockcroft; Ian B Wilkinson Journal: J Am Coll Cardiol Date: 2013-11-13 Impact factor: 24.094