Literature DB >> 19179659

Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.

Elvira Haas1, Indranil Bhattacharya, Eugen Brailoiu, Marlen Damjanović, G Cristina Brailoiu, Xin Gao, Laurence Mueller-Guerre, Nicole A Marjon, André Gut, Roberta Minotti, Matthias R Meyer, Kerstin Amann, Emerita Ammann, Ana Perez-Dominguez, Michele Genoni, Deborah J Clegg, Nae J Dun, Thomas C Resta, Eric R Prossnitz, Matthias Barton.   

Abstract

We found that the selective stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from cardiovascular disease and obesity.

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Year:  2009        PMID： 19179659      PMCID： PMC2782532          DOI： 10.1161/CIRCRESAHA.108.190892

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  17 in total

1.  Fluctuations of radial artery distensibility throughout the menstrual cycle.

Authors:  C Giannattasio; M Failla; A Grappiolo; M L Stella; A Del Bo; M Colombo; G Mancia
Journal:  Arterioscler Thromb Vasc Biol       Date:  1999-08       Impact factor: 8.311

2.  Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor alpha and estrogen receptor beta.

Authors:  A Nadal; A B Ropero; O Laribi; M Maillet; E Fuentes; B Soria
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205

3.  A transmembrane intracellular estrogen receptor mediates rapid cell signaling.

Authors:  Chetana M Revankar; Daniel F Cimino; Larry A Sklar; Jeffrey B Arterburn; Eric R Prossnitz
Journal:  Science       Date:  2005-02-10       Impact factor: 47.728

4.  Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids.

Authors:  E E Schmidt; D S Taylor; J R Prigge; S Barnett; M R Capecchi
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

5.  Contractile responses to histamine, serotonin, and angiotensin II are impaired by 17 beta-estradiol in human internal mammary arteries in vitro.

Authors:  A Mügge; M Barton; H G Fieguth; M Riedel
Journal:  Pharmacology       Date:  1997-03       Impact factor: 2.547

Review 6.  Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.

Authors:  Eric R Prossnitz; Jeffrey B Arterburn; Harriet O Smith; Tudor I Oprea; Larry A Sklar; Helen J Hathaway
Journal:  Annu Rev Physiol       Date:  2008       Impact factor: 19.318

7.  Differential effects of 17beta-estradiol on function and expression of estrogen receptor alpha, estrogen receptor beta, and GPR30 in arteries and veins of patients with atherosclerosis.

Authors:  Elvira Haas; Matthias R Meyer; Ulrich Schurr; Indranil Bhattacharya; Roberta Minotti; Hung H Nguyen; Andres Heigl; Mario Lachat; Michele Genoni; Matthias Barton
Journal:  Hypertension       Date:  2007-04-23       Impact factor: 10.190

8.  Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.

Authors:  Ulrika E A Mårtensson; S Albert Salehi; Sara Windahl; Maria F Gomez; Karl Swärd; Joanna Daszkiewicz-Nilsson; Anna Wendt; Niklas Andersson; Per Hellstrand; Per-Olof Grände; Christer Owman; Clifford J Rosen; Martin L Adamo; Ingmar Lundquist; Patrik Rorsman; Bengt-Olof Nilsson; Claes Ohlsson; Björn Olde; L M Fredrik Leeb-Lundberg
Journal:  Endocrinology       Date:  2008-10-09       Impact factor: 4.736

9.  Endothelium independent relaxation of human coronary arteries by 17 beta-oestradiol in vitro.

Authors:  A Mügge; M Riedel; M Barton; M Kuhn; P R Lichtlen
Journal:  Cardiovasc Res       Date:  1993-11       Impact factor: 10.787

10.  Virtual and biomolecular screening converge on a selective agonist for GPR30.

Authors:  Cristian G Bologa; Chetana M Revankar; Susan M Young; Bruce S Edwards; Jeffrey B Arterburn; Alexander S Kiselyov; Matthew A Parker; Sergey E Tkachenko; Nikolay P Savchuck; Larry A Sklar; Tudor I Oprea; Eric R Prossnitz
Journal:  Nat Chem Biol       Date:  2006-03-05       Impact factor: 15.040
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  163 in total

Review 1.  Mechanism of cardioprotection: what can we learn from females?

Authors:  Elizabeth Murphy; Claudia Lagranha; Anne Deschamps; Mark Kohr; Tiffany Nguyen; Renee Wong; Junhui Sun; Charles Steenbergen
Journal:  Pediatr Cardiol       Date:  2011-01-29       Impact factor: 1.655

2.  Increased estrogen receptor alpha in experimental aortic aneurysms in females compared with males.

Authors:  Adriana Laser; Abhijit Ghosh; Karen Roelofs; Omar Sadiq; Brendan McEvoy; Paul DiMusto; Jon Eliason; Gilbert R Upchurch
Journal:  J Surg Res       Date:  2013-08-18       Impact factor: 2.192

Review 3.  Mechanisms for Sex Differences in Energy Homeostasis.

Authors:  Chunmei Wang; Yong Xu
Journal:  J Mol Endocrinol       Date:  2019-02-01       Impact factor: 5.098

Review 4.  Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease.

Authors:  Durr-e-Nayab Masood; Emir C Roach; Katie G Beauregard; Raouf A Khalil
Journal:  Curr Drug Metab       Date:  2010-10       Impact factor: 3.731

Review 5.  Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.

Authors:  M R Meyer; D J Clegg; E R Prossnitz; M Barton
Journal:  Acta Physiol (Oxf)       Date:  2011-02-01       Impact factor: 6.311

Review 6.  Targeting BKCa Channels in Migraine: Rationale and Perspectives.

Authors:  Mohammad Al-Mahdi Al-Karagholi; Christian Gram; Cherie Amalie Waldorff Nielsen; Messoud Ashina
Journal:  CNS Drugs       Date:  2020-04       Impact factor: 5.749

Review 7.  Emerging roles of GPER in diabetes and atherosclerosis.

Authors:  Matthias Barton; Eric R Prossnitz
Journal:  Trends Endocrinol Metab       Date:  2015-03-09       Impact factor: 12.015

8.  Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1.

Authors:  Harshal Waghulde; Xi Cheng; Sarah Galla; Blair Mell; Jingwei Cai; Shondra M Pruett-Miller; Guillermo Vazquez; Andrew Patterson; Matam Vijay Kumar; Bina Joe
Journal:  Hypertension       Date:  2018-11       Impact factor: 10.190

9.  Subtype-specific estrogen receptor-mediated vasodilator activity in the cephalic, thoracic, and abdominal vasculature of female rat.

Authors:  Ossama M Reslan; Zongzhi Yin; Graciliano R A do Nascimento; Raouf A Khalil
Journal:  J Cardiovasc Pharmacol       Date:  2013-07       Impact factor: 3.105

Review 10.  Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER.

Authors:  Eric R Prossnitz; Matthias Barton
Journal:  Prostaglandins Other Lipid Mediat       Date:  2009-05-13       Impact factor: 3.072
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