| Literature DB >> 19179077 |
Chan Mug Ahn1, Byong-Gon Park, Ho Bum Woo, Jungyeob Ham, Woon-Seob Shin, Seokjoon Lee.
Abstract
In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits.Entities:
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Year: 2009 PMID： 19179077 DOI： 10.1016/j.bmcl.2009.01.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823