| Literature DB >> 19179075 |
Mingzhe Liu1, Takuma Kagahara, Hiroshi Abe, Yoshihiro Ito.
Abstract
Catalytic RNAs with peroxidase activity were obtained by the in vitro selection of RNA aptamer-binding hemin. One of the RNA aptamers selected showed binding affinity to hemin with a dissociation constant of 0.8muM and exhibited high peroxidase activity by forming a complex with hemin. The catalytic efficiency of the RNA-hemin complex was 10-fold higher than that of hemin alone.Entities:
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Year: 2009 PMID： 19179075 DOI： 10.1016/j.bmcl.2009.01.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823