BACKGROUND: While antipsychotic-free schizophrenia patients showed a high degree of within-subject variability in dopamine D(2) receptor density over 6-24 months, no study has examined the long-term stability of D(2) receptor measures in medicated patients. METHODS: Four schizophrenia patients receiving a stable dose of risperidone underwent [(11)C]raclopride positron emission tomography scans on two occasions 5-14 months apart. RESULTS: Plasma risperidone levels were found to be consistent between scans, and consistencies of nondisplaceable D(2) binding potential and D(2) occupancy were good. CONCLUSIONS: The finding supports the validity of quantification of D(2) receptor binding in longitudinal PET studies of medicated patients with schizophrenia.
BACKGROUND: While antipsychotic-free schizophreniapatients showed a high degree of within-subject variability in dopamine D(2) receptor density over 6-24 months, no study has examined the long-term stability of D(2) receptor measures in medicated patients. METHODS: Four schizophreniapatients receiving a stable dose of risperidone underwent [(11)C]raclopride positron emission tomography scans on two occasions 5-14 months apart. RESULTS: Plasma risperidone levels were found to be consistent between scans, and consistencies of nondisplaceable D(2) binding potential and D(2) occupancy were good. CONCLUSIONS: The finding supports the validity of quantification of D(2) receptor binding in longitudinal PET studies of medicated patients with schizophrenia.
Authors: Shinichiro Nakajima; Hiroyuki Uchida; Robert R Bies; Fernando Caravaggio; Takefumi Suzuki; Eric Plitman; Wanna Mar; Philip Gerretsen; Bruce G Pollock; Benoit H Mulsant; David C Mamo; Ariel Graff-Guerrero Journal: Schizophr Bull Date: 2015-07-28 Impact factor: 9.306
Authors: Aine M Duffy; Megan L Fitzgerald; June Chan; Danielle C Robinson; Teresa A Milner; Kenneth Mackie; Virginia M Pickel Journal: Synapse Date: 2011-12 Impact factor: 2.562
Authors: Ursula F Bailer; Guido K Frank; Julie C Price; Carolyn C Meltzer; Carl Becker; Chester A Mathis; Angela Wagner; Nicole C Barbarich-Marsteller; Cinnamon S Bloss; Karen Putnam; Nicholas J Schork; Anthony Gamst; Walter H Kaye Journal: Psychiatry Res Date: 2012-11-13 Impact factor: 3.222
Authors: Samuel Asensio; Maria J Romero; Francisco J Romero; Christopher Wong; Nelly Alia-Klein; Dardo Tomasi; Gene-Jack Wang; Frank Telang; Nora D Volkow; Rita Z Goldstein Journal: Synapse Date: 2010-05 Impact factor: 2.562