OBJECTIVE: Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study, we investigated whether SNPs in this gene were associated with T1D in the Han Chinese population. DESIGN AND METHODS: In this case-controlled association study, a total of 205 T1D patients and 422 non-diabetic subjects of the Han Chinese population were enrolled. Two SNPs, namely, rs17802927 and rs725613, in the KIAA0350 gene were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocol. RESULTS: The intron SNP rs725613 was strongly associated with T1D in the Han Chinese population [P = 0.00007, odds ratio (OR) = 0.527, 95% confidence interval (CI) = 0.383-0.726], and the frequencies of its genotypes in the T1D group significantly differed from those in the control group (P = 0.0001). CONCLUSION: The intron polymorphism rs725613 in the KIAA0350 gene is associated with susceptibility to T1D, and this association is not race specific.
OBJECTIVE: Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study, we investigated whether SNPs in this gene were associated with T1D in the Han Chinese population. DESIGN AND METHODS: In this case-controlled association study, a total of 205 T1D patients and 422 non-diabetic subjects of the Han Chinese population were enrolled. Two SNPs, namely, rs17802927 and rs725613, in the KIAA0350 gene were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocol. RESULTS: The intron SNP rs725613 was strongly associated with T1D in the Han Chinese population [P = 0.00007, odds ratio (OR) = 0.527, 95% confidence interval (CI) = 0.383-0.726], and the frequencies of its genotypes in the T1D group significantly differed from those in the control group (P = 0.0001). CONCLUSION: The intron polymorphism rs725613 in the KIAA0350 gene is associated with susceptibility to T1D, and this association is not race specific.
Authors: Ning Wang; Nan Shen; Timothy J Vyse; Vidya Anand; Iva Gunnarson; Gunnar Sturfelt; Solbritt Rantapää-Dahlqvist; Kerstin Elvin; Lennart Truedsson; Bengt A Andersson; Charlotte Dahle; Eva Ortqvist; Peter K Gregersen; Timothy W Behrens; Lennart Hammarström Journal: Mol Med Date: 2011-08-04 Impact factor: 6.354
Authors: Beate Skinningsrud; Benedicte A Lie; Eystein S Husebye; Tore K Kvien; Øystein Førre; Berit Flatø; Alice Stormyr; Geir Joner; Pål R Njølstad; Thore Egeland; Dag E Undlien Journal: Ann Rheum Dis Date: 2009-09-03 Impact factor: 19.103