OBJECTIVES: Comparative evaluation of cardiac dysautonomia in spinocerebellar ataxias (SCA) and idiopathic sporadic ataxias (IA) not fulfilling the criteria of multiple system atrophy. MATERIAL AND METHODS: Cardiac autonomic functions were evaluated in 14 SCA (SCA1 = 6, SCA2 = 5 and SCA3 = 3) and 10 IA patients, comparable for age, age at onset, duration and severity of illness. The results were categorized as early, definitive, or severe autonomic involvement (EI, DI and SI respectively) based on the degree of abnormalities on tests of parasympathetic and sympathetic pathways. RESULTS: Cardiac autonomic dysfunction was present in all (EI = 25.0%, DI = 41.7% and SI = 33.3%), parasympathetic dysfunction being an early feature. SI was most often present in SCA3 (100%), followed by those with SCA1 (66.7%), and SCA2 (20%) and none in IA. CONCLUSIONS: Cardiac dysautonomia was common in both SCA and IA, although the severity was greater in SCA. Among SCAs, the severity was greatest in SCA3, followed by SCA2 and least in SCA1.
OBJECTIVES: Comparative evaluation of cardiac dysautonomia in spinocerebellar ataxias (SCA) and idiopathic sporadic ataxias (IA) not fulfilling the criteria of multiple system atrophy. MATERIAL AND METHODS: Cardiac autonomic functions were evaluated in 14 SCA (SCA1 = 6, SCA2 = 5 and SCA3 = 3) and 10 IApatients, comparable for age, age at onset, duration and severity of illness. The results were categorized as early, definitive, or severe autonomic involvement (EI, DI and SI respectively) based on the degree of abnormalities on tests of parasympathetic and sympathetic pathways. RESULTS:Cardiac autonomic dysfunction was present in all (EI = 25.0%, DI = 41.7% and SI = 33.3%), parasympathetic dysfunction being an early feature. SI was most often present in SCA3 (100%), followed by those with SCA1 (66.7%), and SCA2 (20%) and none in IA. CONCLUSIONS:Cardiac dysautonomia was common in both SCA and IA, although the severity was greater in SCA. Among SCAs, the severity was greatest in SCA3, followed by SCA2 and least in SCA1.
Authors: Anna De Rosa; Sabina Pappatà; Teresa Pellegrino; Maria Fulvia De Leva; Gennaro Maddaluno; Giovanni Fiumara; Raffaella Carotenuto; Mario Petretta; Alessandro Filla; Giuseppe De Michele; Alberto Cuocolo Journal: Eur J Nucl Med Mol Imaging Date: 2013-08-09 Impact factor: 9.236
Authors: Elisabetta Indelicato; Alessandra Fanciulli; Jean Pierre Ndayisaba; Wolfgang Nachbauer; Roberta Granata; Julia Wanschitz; Michaela Wagner; Elke R Gizewski; Werner Poewe; Gregor K Wenning; Sylvia Boesch Journal: Clin Auton Res Date: 2018-02-12 Impact factor: 4.435
Authors: Adriana Moro; Mariana Moscovich; Marina Farah; Carlos Henrique F Camargo; Hélio A G Teive; Renato P Munhoz Journal: Cerebellum Ataxias Date: 2019-08-27
Authors: Alhassane Diallo; Heike Jacobi; Tanja Schmitz-Hübsch; Arron Cook; Robyn Labrum; Alexandra Durr; Alexis Brice; Perrine Charles; Cecilia Marelli; Caterina Mariotti; Lorenzo Nanetti; Marta Panzeri; Maria Rakowicz; Anna Sobanska; Anna Sulek; Ludger Schöls; Holger Hengel; Bela Melegh; Alessandro Filla; Antonella Antenora; Jon Infante; José Berciano; Bart P van de Warrenburg; Dagmar Timmann; Sylvia Boesch; Massimo Pandolfo; Jörg B Schulz; Peter Bauer; Paola Giunti; Laszlo Baliko; Michael H Parkinson; Jun-Suk Kang; Thomas Klockgether; Sophie Tezenas du Montcel Journal: Mov Disord Clin Pract Date: 2017-08-11