| Literature DB >> 19178357 |
Thomas M Razler1, Yi Hsiao, Feng Qian, Ruiling Fu, Rana Kashif Khan, Wendel Doubleday.
Abstract
A ligand-free Suzuki-Miyaura reaction for the cross-coupling of aryl and heteroaryl bromides with aryl and heteroarylboronic acids has been developed utilizing catalytic polyethylene glycol 2000 (PEG 2000). This preparatively convenient system afforded the corresponding cross-coupled products in good to excellent isolated yields after a simple aqueous workup. Transmission electron microscopy (TEM) analysis of the Pd-PEG 2000 catalyst system revealed in situ-generated palladium nanoparticles after only 1 min of reaction.Entities:
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Year: 2009 PMID： 19178357 DOI： 10.1021/jo802277z
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354