BACKGROUND: Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers. METHODS: We assessed clinical status and 16 biomarkers within 24 h of onset in 180 consecutive acute ischaemic stroke patients. RESULTS: A total of 94 patients had a poor outcome (dead or dependent at 30 days). C-reactive protein (CRP), IL-6, and fibrin D-dimer showed the strongest univariate associations with poor outcome (>2-fold increase; p < 0.01). When all biomarkers were included with clinical variables in a multivariable model, only D-dimer (OR 1.54; 95% CI 1.09-2.17), CRP (OR 1.31; 95% CI 1.03-1.68) and Scandinavian Stroke Scale (OR 0.91; 95% CI 0.88-0.95) were associated with poor outcome. CONCLUSIONS: D-dimer and CRP are independently associated with poor outcome in acute ischaemic stroke. More data is required to expand our understanding of these potential relationships with outcome.
BACKGROUND: Many inflammatory and haemostatic biomarkers show associations with acute ischaemic stroke outcome, but few studies compare a large range of markers. METHODS: We assessed clinical status and 16 biomarkers within 24 h of onset in 180 consecutive acute ischaemic strokepatients. RESULTS: A total of 94 patients had a poor outcome (dead or dependent at 30 days). C-reactive protein (CRP), IL-6, and fibrin D-dimer showed the strongest univariate associations with poor outcome (>2-fold increase; p < 0.01). When all biomarkers were included with clinical variables in a multivariable model, only D-dimer (OR 1.54; 95% CI 1.09-2.17), CRP (OR 1.31; 95% CI 1.03-1.68) and Scandinavian Stroke Scale (OR 0.91; 95% CI 0.88-0.95) were associated with poor outcome. CONCLUSIONS: D-dimer and CRP are independently associated with poor outcome in acute ischaemic stroke. More data is required to expand our understanding of these potential relationships with outcome.
Authors: David Skoloudík; Michal Bar; Daniel Sanák; Petr Bardon; Martin Roubec; Katerina Langová; Roman Herzig; Petr Kanovský Journal: J Thromb Thrombolysis Date: 2010-05 Impact factor: 2.300
Authors: Jeffrey A Switzer; Andrea Sikora; Adviye Ergul; Jennifer L Waller; David C Hess; Susan C Fagan Journal: Transl Stroke Res Date: 2012-03-15 Impact factor: 6.829
Authors: William Whiteley; Caroline Jackson; Steff Lewis; Gordon Lowe; Ann Rumley; Peter Sandercock; Joanna Wardlaw; Martin Dennis; Cathie Sudlow Journal: PLoS Med Date: 2009-09-08 Impact factor: 11.069