Literature DB >> 19176622

Identification of potential recombination breakpoints in human parechoviruses.

Jan Zoll1, Jochem M D Galama, Frank J M van Kuppeveld.   

Abstract

Based on a comparison of the phylogeny of two distant regions, evidence has been found for recombination within parechoviruses. However, recombination breakpoints could not be detected in this way. We searched for potential recombination breakpoints in parechovirus by analysis of complete parechovirus sequences, including a newly isolated strain. Bootscan analysis demonstrated that parechoviruses are mosaic viruses build of regions related to corresponding genomic regions of other parechoviruses. With a genetic algorithm for recombination detection, sites for recombination were found. Analysis of partial sequences, as defined by recombination breakpoints, showed phylogenetic segregation between regions.

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Year:  2009        PMID： 19176622      PMCID： PMC2655564          DOI： 10.1128/JVI.02529-08

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

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